Copper in PDB 7wx1: E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris)

All present enzymatic activity of E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris):
1.15.1.1;

The structure of E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris), PDB code: 7wx1 was solved by S.Narikiyo, Y.Furukawa, M.Akutsu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.48 / 1.65
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	37.511, 50.17, 185.751, 90, 90, 90
R / Rfree (%)	23.1 / 26.2

The structure of E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris) also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Copper atom in the E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris) (pdb code 7wx1). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris), PDB code: 7wx1:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu202 b:38.7 occ:1.00 NE2 A:HIS48 2.0 38.2 1.0 ND1 A:HIS46 2.1 42.1 1.0 NE2 A:HIS120 2.1 45.2 1.0 CE1 A:HIS48 2.8 37.2 1.0 CG A:HIS46 3.0 45.0 1.0 NE2 A:HIS63 3.0 37.5 1.0 CE1 A:HIS120 3.1 40.4 1.0 CD2 A:HIS120 3.1 44.1 1.0 CD2 A:HIS48 3.1 34.8 1.0 CE1 A:HIS46 3.1 45.3 1.0 CB A:HIS46 3.2 39.2 1.0 CD2 A:HIS63 3.6 39.5 1.0 O A:HOH348 3.6 49.1 1.0 CE1 A:HIS63 3.9 41.1 1.0 ND1 A:HIS48 4.0 37.7 1.0 CB A:VAL118 4.0 34.3 1.0 CG1 A:VAL118 4.0 35.5 1.0 ND1 A:HIS120 4.1 37.3 1.0 CG A:HIS48 4.1 34.8 1.0 CD2 A:HIS46 4.2 45.8 1.0 CG A:HIS120 4.2 41.9 1.0 CA A:HIS46 4.2 37.5 1.0 NE2 A:HIS46 4.2 42.8 1.0 N A:HIS46 4.2 34.5 1.0 O A:VAL118 4.3 33.7 1.0 CG A:HIS63 4.6 39.1 1.0 C A:HIS46 4.7 36.5 1.0 O A:HIS46 4.7 35.6 1.0 ND1 A:HIS63 4.7 38.6 1.0 CG2 A:VAL118 4.8 35.7 1.0 C A:VAL118 4.9 40.3 1.0

Copper binding site 2 out of 2 in the E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of E40K/M117L Variant of Cu/Zn-Superoxide Dismutase From Dog (Canis Familiaris) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu202 b:32.7 occ:1.00 NE2 B:HIS120 2.0 32.5 1.0 ND1 B:HIS46 2.0 31.5 1.0 NE2 B:HIS48 2.0 28.0 1.0 CD2 B:HIS120 2.9 30.7 1.0 CE1 B:HIS46 2.9 29.1 1.0 CG B:HIS46 3.0 30.7 1.0 CE1 B:HIS120 3.0 31.5 1.0 CD2 B:HIS48 3.0 26.9 1.0 CE1 B:HIS48 3.1 28.9 1.0 NE2 B:HIS63 3.3 33.5 1.0 CB B:HIS46 3.3 29.2 1.0 CD2 B:HIS63 3.7 31.4 1.0 O B:HOH366 4.0 44.2 1.0 CB B:VAL118 4.0 29.3 1.0 CG B:HIS120 4.1 32.0 1.0 ND1 B:HIS120 4.1 33.0 1.0 NE2 B:HIS46 4.1 30.4 1.0 CD2 B:HIS46 4.1 31.9 1.0 CE1 B:HIS63 4.1 32.1 1.0 ND1 B:HIS48 4.1 28.6 1.0 CG B:HIS48 4.2 28.8 1.0 N B:HIS46 4.2 29.0 1.0 CG1 B:VAL118 4.3 31.5 1.0 CA B:HIS46 4.3 29.0 1.0 O B:VAL118 4.4 27.0 1.0 O B:HIS46 4.6 30.6 1.0 CG2 B:VAL118 4.6 29.6 1.0 CG B:HIS63 4.7 30.5 1.0 C B:HIS46 4.7 28.4 1.0 ND1 B:HIS63 4.9 29.4 1.0 C B:VAL118 4.9 30.2 1.0 CA B:VAL118 5.0 29.5 1.0

S.Narikiyo, Y.Furukawa, M.Akutsu. Crystal Structure of Dog Superoxide Dismutase To Be Published.