Copper in PDB 7kbt: Factor VIII in Complex with the Anti-C2 Domain Antibody, G99

The structure of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99, PDB code: 7kbt was solved by E.K.Ronayne, J.Gish, C.Wilson, S.Peters, H.T.Spencer, P.C.Spiegel, K.C.Childers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.48 / 4.15
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	132.243, 132.243, 380.029, 90.00, 90.00, 90.00
R / Rfree (%)	30 / 33.8

The structure of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 also contains other interesting chemical elements:

Calcium	(Ca)	1 atom
Zinc	(Zn)	1 atom

The binding sites of Copper atom in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 (pdb code 7kbt). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99, PDB code: 7kbt:

Copper binding site 1 out of 1 in the Factor VIII in Complex with the Anti-C2 Domain Antibody, G99


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Factor VIII in Complex with the Anti-C2 Domain Antibody, G99 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu2402 b:0.3 occ:1.00 ND1 A:HIS1954 2.2 0.2 1.0 SG A:CYS2000 2.3 0.7 1.0 CD2 A:HIS2005 2.6 0.7 1.0 CB A:HIS1954 2.6 1.0 1.0 CG A:HIS1954 2.7 1.0 1.0 CA A:HIS1954 2.8 0.0 1.0 CG1 A:ILE2002 3.1 0.1 1.0 CE1 A:HIS1954 3.4 0.9 1.0 NE2 A:HIS2005 3.5 0.7 1.0 CB A:ILE2002 3.6 0.3 1.0 CG A:HIS2005 3.6 0.5 1.0 N A:HIS1954 3.7 0.7 1.0 CB A:CYS2000 3.8 0.6 1.0 C A:HIS1954 3.9 0.6 1.0 N A:SER1955 3.9 0.2 1.0 CD2 A:HIS1954 4.0 0.2 1.0 CB A:HIS2005 4.1 0.5 1.0 NE2 A:HIS1954 4.3 0.4 1.0 SD A:MET2010 4.3 0.0 1.0 CG2 A:ILE2002 4.3 0.8 1.0 C A:ILE1953 4.4 0.1 1.0 CD1 A:ILE2002 4.5 0.2 1.0 O A:ILE1953 4.5 0.1 1.0 CE1 A:HIS2005 4.6 0.4 1.0 ND1 A:HIS2005 4.7 0.6 1.0 CA A:ILE2002 4.8 0.4 1.0 N A:ILE2002 4.8 0.0 1.0 CA A:CYS2000 5.0 0.3 1.0

E.K.Ronayne, J.Gish, C.Wilson, S.Peters, H.T.Spencer, P.C.Spiegel, K.C.Childers. Structure of A Bioengineered Variant of Factor VIII in Complex with the Anti-C2 Domain, Non-Classical Antibody Inhibitor, G99 To Be Published.