Copper in PDB 1azv: Familial Als Mutant G37R Cuznsod (Human)

All present enzymatic activity of Familial Als Mutant G37R Cuznsod (Human):
1.15.1.1;

The structure of Familial Als Mutant G37R Cuznsod (Human), PDB code: 1azv was solved by P.J.Hart, H.Liu, M.Pellegrini, A.M.Nersissian, E.B.Gralla, J.S.Valentine, D.Eisenberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 1.90
Space group	P 41
Cell size a, b, c (Å), α, β, γ (°)	67.200, 67.200, 83.800, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 24.4

The structure of Familial Als Mutant G37R Cuznsod (Human) also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Copper atom in the Familial Als Mutant G37R Cuznsod (Human) (pdb code 1azv). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Familial Als Mutant G37R Cuznsod (Human), PDB code: 1azv:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the Familial Als Mutant G37R Cuznsod (Human)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Familial Als Mutant G37R Cuznsod (Human) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu154 b:40.1 occ:1.00 NE2 A:HIS120 2.1 27.0 1.0 ND1 A:HIS46 2.2 19.9 1.0 NE2 A:HIS48 2.3 29.4 1.0 NE2 A:HIS63 2.6 28.6 1.0 CD2 A:HIS120 2.8 24.0 1.0 CD2 A:HIS63 3.1 24.4 1.0 CG A:HIS46 3.2 18.3 1.0 CE1 A:HIS46 3.2 19.1 1.0 CE1 A:HIS120 3.2 26.2 1.0 CE1 A:HIS48 3.2 26.7 1.0 CD2 A:HIS48 3.3 25.9 1.0 CB A:HIS46 3.4 19.2 1.0 CE1 A:HIS63 3.7 23.8 1.0 CG A:HIS120 4.0 26.1 1.0 ND1 A:HIS120 4.1 25.9 1.0 O A:HOH428 4.2 40.5 1.0 NE2 A:HIS46 4.3 19.2 1.0 CG A:HIS63 4.3 23.9 1.0 CD2 A:HIS46 4.3 18.7 1.0 ND1 A:HIS48 4.3 25.6 1.0 CG A:HIS48 4.4 23.6 1.0 ND1 A:HIS63 4.5 20.8 1.0 CA A:HIS46 4.5 17.5 1.0 N A:HIS46 4.6 19.7 1.0 CB A:VAL118 4.9 21.2 1.0 CG1 A:VAL118 4.9 19.9 1.0 O A:HIS46 4.9 19.4 1.0 C A:HIS46 5.0 17.2 1.0

Copper binding site 2 out of 2 in the Familial Als Mutant G37R Cuznsod (Human)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Familial Als Mutant G37R Cuznsod (Human) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu154 b:28.4 occ:1.00 NE2 B:HIS120 2.0 16.9 1.0 ND1 B:HIS46 2.1 18.9 1.0 NE2 B:HIS48 2.1 12.4 1.0 CE1 B:HIS120 3.0 14.6 1.0 CD2 B:HIS120 3.0 16.0 1.0 CG B:HIS46 3.0 17.1 1.0 CE1 B:HIS48 3.0 12.8 1.0 CE1 B:HIS46 3.1 17.1 1.0 NE2 B:HIS63 3.1 28.7 1.0 CD2 B:HIS48 3.2 12.6 1.0 CB B:HIS46 3.3 13.8 1.0 CD2 B:HIS63 3.5 24.6 1.0 CG2 B:VAL118 3.9 18.6 1.0 ND1 B:HIS120 4.1 15.0 1.0 CG B:HIS120 4.1 15.9 1.0 NE2 B:HIS46 4.1 17.3 1.0 CD2 B:HIS46 4.2 17.1 1.0 CE1 B:HIS63 4.2 25.9 1.0 ND1 B:HIS48 4.2 15.0 1.0 CG B:HIS48 4.3 13.8 1.0 CA B:HIS46 4.4 14.3 1.0 N B:HIS46 4.5 14.9 1.0 CG B:HIS63 4.6 21.7 1.0 O B:HOH509 4.7 40.7 1.0 O B:HIS46 4.8 14.9 1.0 C B:HIS46 4.8 15.1 1.0 ND1 B:HIS63 4.9 20.3 1.0 O B:VAL118 5.0 14.6 1.0 CB B:VAL118 5.0 18.8 1.0

P.J.Hart, H.Liu, M.Pellegrini, A.M.Nersissian, E.B.Gralla, J.S.Valentine, D.Eisenberg. Subunit Asymmetry in the Three-Dimensional Structure of A Human Cuznsod Mutant Found in Familial Amyotrophic Lateral Sclerosis. Protein Sci. V. 7 545 1998.
ISSN: ISSN 0961-8368
PubMed: 9541385