Copper in PDB 8x7p: Cca-Bound E46K Alpha-Synuclein Fibrils

The binding sites of Copper atom in the Cca-Bound E46K Alpha-Synuclein Fibrils (pdb code 8x7p). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 8 binding sites of Copper where determined in the Cca-Bound E46K Alpha-Synuclein Fibrils, PDB code: 8x7p:
Jump to Copper binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Copper binding site 1 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu201 b:63.3 occ:1.00 CU1 A:V79201 0.0 63.3 1.0 N37 A:V79201 1.9 63.3 1.0 N22 A:V79201 2.0 63.3 1.0 N10 A:V79201 2.0 63.3 1.0 N20 A:V79201 2.1 63.3 1.0 C11 A:V79201 2.8 63.3 1.0 C44 A:V79201 2.8 63.3 1.0 C09 A:V79201 3.0 63.3 1.0 C23 A:V79201 3.0 63.3 1.0 C19 A:V79201 3.0 63.3 1.0 C30 A:V79201 3.0 63.3 1.0 C38 A:V79201 3.1 63.3 1.0 C13 A:V79201 3.1 63.3 1.0 C45 A:V79201 3.4 63.3 1.0 C32 A:V79201 3.4 63.3 1.0 C12 A:V79201 3.4 63.3 1.0 C31 A:V79201 3.6 63.3 1.0 C31 B:V79201 3.9 63.3 1.0 C30 B:V79201 4.0 63.3 1.0 C12 E:V79201 4.0 63.3 1.0 C38 B:V79201 4.1 63.3 1.0 C02 A:V79201 4.1 63.3 1.0 C28 A:V79201 4.1 63.3 1.0 C11 E:V79201 4.1 63.3 1.0 C24 A:V79201 4.2 63.3 1.0 C03 A:V79201 4.2 63.3 1.0 C42 A:V79201 4.2 63.3 1.0 C13 E:V79201 4.2 63.3 1.0 C39 A:V79201 4.2 63.3 1.0 C16 A:V79201 4.3 63.3 1.0 C14 A:V79201 4.3 63.3 1.0 N22 B:V79201 4.3 63.3 1.0 C28 B:V79201 4.4 63.3 1.0 N10 E:V79201 4.5 63.3 1.0 N37 B:V79201 4.5 63.3 1.0 N20 E:V79201 4.6 63.3 1.0 C39 B:V79201 4.6 63.3 1.0 C02 E:V79201 4.6 63.3 1.0 C41 B:V79201 4.6 63.3 1.0 C33 A:V79201 4.6 63.3 1.0 C14 E:V79201 4.8 63.3 1.0 C29 B:V79201 4.9 63.3 1.0 CU1 B:V79201 4.9 63.3 1.0 CU1 E:V79201 5.0 63.3 1.0

Copper binding site 2 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu201 b:63.3 occ:1.00 CU1 B:V79201 0.0 63.3 1.0 N37 B:V79201 1.9 63.3 1.0 N22 B:V79201 2.0 63.3 1.0 N10 B:V79201 2.0 63.3 1.0 N20 B:V79201 2.1 63.3 1.0 C11 B:V79201 2.8 63.3 1.0 C44 B:V79201 2.8 63.3 1.0 C09 B:V79201 3.0 63.3 1.0 C23 B:V79201 3.0 63.3 1.0 C19 B:V79201 3.0 63.3 1.0 C30 B:V79201 3.0 63.3 1.0 C38 B:V79201 3.1 63.3 1.0 C13 B:V79201 3.1 63.3 1.0 C45 B:V79201 3.4 63.3 1.0 C32 B:V79201 3.4 63.3 1.0 C12 B:V79201 3.4 63.3 1.0 C31 B:V79201 3.5 63.3 1.0 C12 A:V79201 3.8 63.3 1.0 C13 A:V79201 3.9 63.3 1.0 C11 A:V79201 4.1 63.3 1.0 C02 B:V79201 4.1 63.3 1.0 C28 B:V79201 4.1 63.3 1.0 C24 B:V79201 4.2 63.3 1.0 C03 B:V79201 4.2 63.3 1.0 C42 B:V79201 4.2 63.3 1.0 C39 B:V79201 4.2 63.3 1.0 C16 B:V79201 4.3 63.3 1.0 C14 B:V79201 4.3 63.3 1.0 N20 A:V79201 4.4 63.3 1.0 C14 A:V79201 4.4 63.3 1.0 N10 A:V79201 4.4 63.3 1.0 C33 B:V79201 4.6 63.3 1.0 C02 A:V79201 4.6 63.3 1.0 C15 A:V79201 4.9 63.3 1.0 CU1 A:V79201 4.9 63.3 1.0

Copper binding site 3 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ C:Cu201 b:63.3 occ:1.00 CU1 C:V79201 0.0 63.3 1.0 N37 C:V79201 1.9 63.3 1.0 N22 C:V79201 2.0 63.3 1.0 N10 C:V79201 2.0 63.3 1.0 N20 C:V79201 2.1 63.3 1.0 C11 C:V79201 2.8 63.3 1.0 C44 C:V79201 2.8 63.3 1.0 C09 C:V79201 3.0 63.3 1.0 C23 C:V79201 3.0 63.3 1.0 C19 C:V79201 3.0 63.3 1.0 C30 C:V79201 3.0 63.3 1.0 C38 C:V79201 3.1 63.3 1.0 C13 C:V79201 3.1 63.3 1.0 C45 C:V79201 3.4 63.3 1.0 C32 C:V79201 3.4 63.3 1.0 C12 C:V79201 3.4 63.3 1.0 C31 C:V79201 3.6 63.3 1.0 C31 D:V79201 3.9 63.3 1.0 C30 D:V79201 4.0 63.3 1.0 C12 G:V79201 4.0 63.3 1.0 C38 D:V79201 4.1 63.3 1.0 C02 C:V79201 4.1 63.3 1.0 C28 C:V79201 4.1 63.3 1.0 C11 G:V79201 4.1 63.3 1.0 C24 C:V79201 4.2 63.3 1.0 C03 C:V79201 4.2 63.3 1.0 C42 C:V79201 4.2 63.3 1.0 C13 G:V79201 4.2 63.3 1.0 C39 C:V79201 4.2 63.3 1.0 C14 C:V79201 4.3 63.3 1.0 C16 C:V79201 4.3 63.3 1.0 N22 D:V79201 4.3 63.3 1.0 C28 D:V79201 4.4 63.3 1.0 N10 G:V79201 4.5 63.3 1.0 N37 D:V79201 4.5 63.3 1.0 N20 G:V79201 4.6 63.3 1.0 C39 D:V79201 4.6 63.3 1.0 C02 G:V79201 4.6 63.3 1.0 C41 D:V79201 4.6 63.3 1.0 C33 C:V79201 4.6 63.3 1.0 C14 G:V79201 4.8 63.3 1.0 C29 D:V79201 4.9 63.3 1.0 CU1 D:V79201 4.9 63.3 1.0 CU1 G:V79201 5.0 63.3 1.0

Copper binding site 4 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 4 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ D:Cu201 b:63.3 occ:1.00 CU1 D:V79201 0.0 63.3 1.0 N37 D:V79201 1.9 63.3 1.0 N22 D:V79201 2.0 63.3 1.0 N10 D:V79201 2.0 63.3 1.0 N20 D:V79201 2.1 63.3 1.0 C11 D:V79201 2.8 63.3 1.0 C44 D:V79201 2.8 63.3 1.0 C09 D:V79201 3.0 63.3 1.0 C23 D:V79201 3.0 63.3 1.0 C19 D:V79201 3.0 63.3 1.0 C30 D:V79201 3.0 63.3 1.0 C38 D:V79201 3.1 63.3 1.0 C13 D:V79201 3.1 63.3 1.0 C45 D:V79201 3.4 63.3 1.0 C32 D:V79201 3.4 63.3 1.0 C12 D:V79201 3.4 63.3 1.0 C31 D:V79201 3.5 63.3 1.0 C12 C:V79201 3.8 63.3 1.0 C13 C:V79201 3.9 63.3 1.0 C11 C:V79201 4.1 63.3 1.0 C02 D:V79201 4.1 63.3 1.0 C28 D:V79201 4.1 63.3 1.0 C24 D:V79201 4.2 63.3 1.0 C03 D:V79201 4.2 63.3 1.0 C42 D:V79201 4.2 63.3 1.0 C39 D:V79201 4.2 63.3 1.0 C16 D:V79201 4.3 63.3 1.0 C14 D:V79201 4.3 63.3 1.0 N20 C:V79201 4.4 63.3 1.0 C14 C:V79201 4.4 63.3 1.0 N10 C:V79201 4.4 63.3 1.0 C33 D:V79201 4.6 63.3 1.0 C02 C:V79201 4.6 63.3 1.0 C15 C:V79201 4.9 63.3 1.0 CU1 C:V79201 4.9 63.3 1.0

Copper binding site 5 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 5 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ E:Cu201 b:63.3 occ:1.00 CU1 E:V79201 0.0 63.3 1.0 N37 E:V79201 1.9 63.3 1.0 N22 E:V79201 2.0 63.3 1.0 N10 E:V79201 2.0 63.3 1.0 N20 E:V79201 2.1 63.3 1.0 C11 E:V79201 2.8 63.3 1.0 C44 E:V79201 2.8 63.3 1.0 C09 E:V79201 3.0 63.3 1.0 C23 E:V79201 3.0 63.3 1.0 C19 E:V79201 3.0 63.3 1.0 C30 E:V79201 3.0 63.3 1.0 C38 E:V79201 3.1 63.3 1.0 C13 E:V79201 3.1 63.3 1.0 C45 E:V79201 3.4 63.3 1.0 C32 E:V79201 3.4 63.3 1.0 C12 E:V79201 3.4 63.3 1.0 C31 E:V79201 3.5 63.3 1.0 C31 A:V79201 3.9 63.3 1.0 C38 A:V79201 4.1 63.3 1.0 C30 A:V79201 4.1 63.3 1.0 C02 E:V79201 4.1 63.3 1.0 C28 E:V79201 4.1 63.3 1.0 C24 E:V79201 4.2 63.3 1.0 C03 E:V79201 4.2 63.3 1.0 C42 E:V79201 4.2 63.3 1.0 C39 E:V79201 4.2 63.3 1.0 C16 E:V79201 4.3 63.3 1.0 C14 E:V79201 4.3 63.3 1.0 N37 A:V79201 4.5 63.3 1.0 N22 A:V79201 4.5 63.3 1.0 C41 A:V79201 4.5 63.3 1.0 C12 I:V79201 4.5 63.3 1.0 C39 A:V79201 4.6 63.3 1.0 C28 A:V79201 4.6 63.3 1.0 C11 I:V79201 4.6 63.3 1.0 C33 E:V79201 4.6 63.3 1.0 C13 I:V79201 4.8 63.3 1.0 N10 I:V79201 4.9 63.3 1.0 C02 I:V79201 5.0 63.3 1.0 CU1 A:V79201 5.0 63.3 1.0

Copper binding site 6 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 6 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ G:Cu201 b:63.3 occ:1.00 CU1 G:V79201 0.0 63.3 1.0 N37 G:V79201 1.9 63.3 1.0 N22 G:V79201 2.0 63.3 1.0 N10 G:V79201 2.0 63.3 1.0 N20 G:V79201 2.1 63.3 1.0 C11 G:V79201 2.8 63.3 1.0 C44 G:V79201 2.8 63.3 1.0 C09 G:V79201 3.0 63.3 1.0 C23 G:V79201 3.0 63.3 1.0 C19 G:V79201 3.0 63.3 1.0 C30 G:V79201 3.0 63.3 1.0 C38 G:V79201 3.1 63.3 1.0 C13 G:V79201 3.1 63.3 1.0 C45 G:V79201 3.4 63.3 1.0 C32 G:V79201 3.4 63.3 1.0 C12 G:V79201 3.4 63.3 1.0 C31 G:V79201 3.5 63.3 1.0 C31 C:V79201 3.9 63.3 1.0 C38 C:V79201 4.1 63.3 1.0 C30 C:V79201 4.1 63.3 1.0 C02 G:V79201 4.1 63.3 1.0 C28 G:V79201 4.1 63.3 1.0 C24 G:V79201 4.2 63.3 1.0 C03 G:V79201 4.2 63.3 1.0 C42 G:V79201 4.2 63.3 1.0 C39 G:V79201 4.2 63.3 1.0 C16 G:V79201 4.3 63.3 1.0 C14 G:V79201 4.3 63.3 1.0 N37 C:V79201 4.5 63.3 1.0 N22 C:V79201 4.5 63.3 1.0 C41 C:V79201 4.5 63.3 1.0 C12 H:V79201 4.5 63.3 1.0 C39 C:V79201 4.6 63.3 1.0 C28 C:V79201 4.6 63.3 1.0 C11 H:V79201 4.6 63.3 1.0 C33 G:V79201 4.6 63.3 1.0 C13 H:V79201 4.8 63.3 1.0 N10 H:V79201 4.9 63.3 1.0 C02 H:V79201 5.0 63.3 1.0 CU1 C:V79201 5.0 63.3 1.0

Copper binding site 7 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 7 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ H:Cu201 b:63.3 occ:1.00 CU1 H:V79201 0.0 63.3 1.0 N37 H:V79201 1.9 63.3 1.0 N22 H:V79201 2.0 63.3 1.0 N10 H:V79201 2.0 63.3 1.0 N20 H:V79201 2.1 63.3 1.0 C11 H:V79201 2.8 63.3 1.0 C44 H:V79201 2.8 63.3 1.0 C09 H:V79201 3.0 63.3 1.0 C23 H:V79201 3.0 63.3 1.0 C19 H:V79201 3.0 63.3 1.0 C30 H:V79201 3.0 63.3 1.0 C38 H:V79201 3.1 63.3 1.0 C13 H:V79201 3.1 63.3 1.0 C45 H:V79201 3.4 63.3 1.0 C32 H:V79201 3.4 63.3 1.0 C12 H:V79201 3.4 63.3 1.0 C31 H:V79201 3.6 63.3 1.0 C02 H:V79201 4.1 63.3 1.0 C28 H:V79201 4.1 63.3 1.0 C24 H:V79201 4.2 63.3 1.0 C03 H:V79201 4.2 63.3 1.0 C42 H:V79201 4.2 63.3 1.0 C39 H:V79201 4.2 63.3 1.0 C14 H:V79201 4.3 63.3 1.0 C16 H:V79201 4.3 63.3 1.0 C31 G:V79201 4.4 63.3 1.0 C38 G:V79201 4.5 63.3 1.0 C41 G:V79201 4.6 63.3 1.0 C33 H:V79201 4.6 63.3 1.0 C30 G:V79201 4.6 63.3 1.0 C39 G:V79201 4.9 63.3 1.0 N37 G:V79201 4.9 63.3 1.0

Copper binding site 8 out of 8 in the Cca-Bound E46K Alpha-Synuclein Fibrils


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 8 of Cca-Bound E46K Alpha-Synuclein Fibrils within 5.0Å range: probe atom residue distance (Å) B Occ I:Cu201 b:63.3 occ:1.00 CU1 I:V79201 0.0 63.3 1.0 N37 I:V79201 1.9 63.3 1.0 N22 I:V79201 2.0 63.3 1.0 N10 I:V79201 2.0 63.3 1.0 N20 I:V79201 2.1 63.3 1.0 C11 I:V79201 2.8 63.3 1.0 C44 I:V79201 2.8 63.3 1.0 C09 I:V79201 3.0 63.3 1.0 C23 I:V79201 3.0 63.3 1.0 C19 I:V79201 3.0 63.3 1.0 C30 I:V79201 3.0 63.3 1.0 C38 I:V79201 3.1 63.3 1.0 C13 I:V79201 3.1 63.3 1.0 C45 I:V79201 3.4 63.3 1.0 C32 I:V79201 3.4 63.3 1.0 C12 I:V79201 3.4 63.3 1.0 C31 I:V79201 3.6 63.3 1.0 C02 I:V79201 4.1 63.3 1.0 C28 I:V79201 4.1 63.3 1.0 C24 I:V79201 4.2 63.3 1.0 C03 I:V79201 4.2 63.3 1.0 C42 I:V79201 4.2 63.3 1.0 C39 I:V79201 4.2 63.3 1.0 C14 I:V79201 4.3 63.3 1.0 C16 I:V79201 4.3 63.3 1.0 C31 E:V79201 4.4 63.3 1.0 C38 E:V79201 4.5 63.3 1.0 C41 E:V79201 4.6 63.3 1.0 C33 I:V79201 4.6 63.3 1.0 C30 E:V79201 4.6 63.3 1.0 C39 E:V79201 4.9 63.3 1.0 N37 E:V79201 4.9 63.3 1.0

K.Liu, Y.Tao, Q.Zhao, W.Xia, X.Li, S.Zhang, Y.Yao, H.Xiang, C.Han, L.Tan, B.Sun, D.Li, A.Li, C.Liu. Binding Adaptability of Chemical Ligands to Polymorphic Alpha-Synuclein Amyloid Fibrils. Proc.Natl.Acad.Sci.Usa V. 121 33121 2024.
ISSN: ESSN 1091-6490
PubMed: 39172784
DOI: 10.1073/PNAS.2321633121