Copper in PDB 8qyb: J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma

The structure of J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma, PDB code: 8qyb was solved by S.F.Marino, O.Daumke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.25 / 3.09
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	137.185, 54.617, 81.084, 90, 121.09, 90
R / Rfree (%)	24.7 / 30.6

The binding sites of Copper atom in the J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma (pdb code 8qyb). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma, PDB code: 8qyb:

Copper binding site 1 out of 1 in the J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of J22.9-Isy, Fully Humanized and Cdr Optimized Fab Fragment Based on Chimeric J22.9-XI Igg Against Bcma within 5.0Å range: probe atom residue distance (Å) B Occ L:Cu301 b:22.5 occ:0.39 H1 L:GLU1 1.2 76.5 1.0 N L:GLU1 1.8 82.0 1.0 H2 L:GLU1 1.9 76.5 1.0 H3 L:GLU1 2.4 76.5 1.0 CA L:GLU1 2.9 81.4 1.0 HA L:GLU1 3.0 71.8 1.0 O L:GLU1 3.7 78.3 1.0 C L:GLU1 3.7 79.0 1.0 HG3 L:GLU1 3.9 70.7 1.0 CB L:GLU1 4.1 78.7 1.0 CG L:GLU1 4.3 81.0 1.0 HG2 L:GLU1 4.4 70.7 1.0 HB2 L:GLU1 4.5 69.5 1.0 HB3 L:GLU1 4.9 69.5 1.0 N L:ILE2 5.0 53.0 1.0

S.F.Marino, O.Daumke. Structure-Based Humanization of A Therapeutic Antibody For Multiple Myeloma To Be Published.