Copper in PDB 8ec0: III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant

All present enzymatic activity of III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant:
7.1.1.8; 7.1.1.9;

The structure of III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant also contains other interesting chemical elements:

Iron

(Fe)

12 atoms

The binding sites of Copper atom in the III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant (pdb code 8ec0). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 3 binding sites of Copper where determined in the III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant, PDB code: 8ec0:
Jump to Copper binding site number: 1; 2; 3;

Copper binding site 1 out of 3 in the III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant within 5.0Å range: probe atom residue distance (Å) B Occ K:Cu601 b:143.0 occ:1.00 NE2 K:HIS290 2.0 135.1 1.0 NE2 K:HIS241 2.0 134.2 1.0 CE1 K:HIS241 2.2 134.2 1.0 CD2 K:HIS290 2.4 135.1 1.0 O K:VAL287 2.5 130.2 1.0 CD2 K:HIS241 2.7 134.2 1.0 ND1 K:HIS241 2.9 134.2 1.0 CG K:HIS241 3.2 134.2 1.0 CE1 K:HIS290 3.2 135.1 1.0 CG K:HIS290 3.7 135.1 1.0 C K:VAL287 3.7 130.2 1.0 ND1 K:HIS290 4.0 135.1 1.0 CB K:VAL287 4.2 130.2 1.0 CG2 K:VAL287 4.2 130.2 1.0 OH K:TYR245 4.4 130.3 1.0 OG1 K:THR309 4.5 122.5 1.0 CB K:HIS241 4.5 134.2 1.0 CA K:VAL287 4.6 130.2 1.0 N K:TRP288 4.7 138.2 1.0 NE2 K:HIS291 4.7 136.7 1.0 CA K:TRP288 4.7 138.2 1.0 CB K:HIS290 4.9 135.1 1.0

Copper binding site 2 out of 3 in the III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant within 5.0Å range: probe atom residue distance (Å) B Occ P:Cu301 b:147.9 occ:1.00 ND1 P:HIS186 2.1 124.3 1.0 SG P:CYS225 2.2 127.0 1.0 SD P:MET232 2.3 126.1 1.0 SG P:CYS221 2.3 128.1 1.0 CU2 P:CUA302 2.8 146.2 1.0 CE1 P:HIS186 2.8 124.3 1.0 CE P:MET232 3.0 126.1 1.0 CG P:HIS186 3.2 124.3 1.0 CB P:CYS221 3.5 128.1 1.0 CB P:HIS186 3.7 124.3 1.0 CB P:CYS225 3.7 127.0 1.0 CG P:MET232 3.7 126.1 1.0 CA P:HIS186 4.0 124.3 1.0 NE2 P:HIS186 4.0 124.3 1.0 O P:GLU223 4.2 125.5 1.0 CD2 P:HIS186 4.2 124.3 1.0 CB P:MET232 4.3 126.1 1.0 ND1 P:HIS229 4.7 128.2 1.0 N P:ASP187 4.7 120.4 1.0 O P:ILE185 4.7 122.3 1.0 CA P:CYS225 4.8 127.0 1.0 CA P:CYS221 4.8 128.1 1.0 C P:HIS186 4.9 124.3 1.0 NE1 P:TRP126 4.9 121.9 1.0 CZ2 P:TRP126 5.0 121.9 1.0 CE2 P:TRP126 5.0 121.9 1.0

Copper binding site 3 out of 3 in the III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of III2IV Respiratory Supercomplex From Saccharomyces Cerevisiae Cardiolipin-Lacking Mutant within 5.0Å range: probe atom residue distance (Å) B Occ P:Cu302 b:146.2 occ:1.00 ND1 P:HIS229 2.1 128.2 1.0 SG P:CYS225 2.2 127.0 1.0 SG P:CYS221 2.3 128.1 1.0 CU1 P:CUA301 2.8 147.9 1.0 CE1 P:HIS229 2.8 128.2 1.0 O P:GLU223 2.9 125.5 1.0 CB P:CYS221 2.9 128.1 1.0 O P:HIS229 3.0 128.2 1.0 CG P:HIS229 3.2 128.2 1.0 CB P:CYS225 3.6 127.0 1.0 CA P:HIS229 3.7 128.2 1.0 C P:HIS229 3.7 128.2 1.0 CB P:HIS229 3.7 128.2 1.0 O P:CYS221 3.7 128.1 1.0 NE2 P:HIS229 3.9 128.2 1.0 SD P:MET232 4.0 126.1 1.0 N P:CYS225 4.0 127.0 1.0 C P:GLU223 4.1 125.5 1.0 CA P:CYS221 4.2 128.1 1.0 CD2 P:HIS229 4.2 128.2 1.0 C P:CYS221 4.2 128.1 1.0 CB P:MET232 4.4 126.1 1.0 CA P:CYS225 4.5 127.0 1.0 C P:LEU224 4.5 125.2 1.0 ND1 P:HIS186 4.6 124.3 1.0 CG P:MET232 4.7 126.1 1.0 N P:GLU223 4.7 125.5 1.0 CA P:LEU224 4.7 125.2 1.0 N P:LEU224 4.9 125.2 1.0 N P:ALA230 5.0 127.5 1.0

C.F.Hryc, V.K.P.S.Mallampalli, E.I.Bovshik, S.Azinas, G.Fan, I.I.Serysheva, G.C.Sparagna, M.L.Baker, E.Mileykovskaya, W.Dowhan. Structural Insights Into Cardiolipin Replacement By Phosphatidylglycerol in A Cardiolipin-Lacking Yeast Respiratory Supercomplex. Nat Commun V. 14 2783 2023.
ISSN: ESSN 2041-1723
PubMed: 37188665
DOI: 10.1038/S41467-023-38441-5