Copper in PDB 8bag: Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine

The structure of Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine, PDB code: 8bag was solved by M.C.Lambert, J.P.Hall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.43 / 1.13
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	21.99, 58.87, 45.46, 90, 90, 90
R / Rfree (%)	15.2 / 17.2

The structure of Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine also contains other interesting chemical elements:

Cobalt

(Co)

5 atoms

The binding sites of Copper atom in the Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine (pdb code 8bag). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine, PDB code: 8bag:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu105 b:29.0 occ:0.39 N7 A:DG5 2.2 17.9 1.0 O A:HOH202 2.5 44.9 0.5 C8 A:DG5 3.2 18.8 1.0 C5 A:DG5 3.2 14.8 1.0 H41 A:DC6 3.3 36.9 1.0 H8 A:DG5 3.3 22.6 1.0 O6 A:DG5 3.4 16.6 1.0 N4 A:DC6 3.6 30.7 1.0 H42 A:DC6 3.6 36.9 1.0 C6 A:DG5 3.6 14.4 1.0 H5'' A:DT4 3.8 36.1 1.0 H4' A:DA3 3.9 14.0 1.0 N9 A:DG5 4.4 17.7 1.0 C4 A:DG5 4.4 14.9 1.0 OP2 A:DG5 4.4 33.0 1.0 C4 A:DC6 4.5 28.0 1.0 O3' A:DA3 4.6 16.0 1.0 C5' A:DT4 4.8 30.0 1.0 H5 A:DC6 4.8 34.4 1.0 C4' A:DA3 4.8 11.6 1.0 H3' A:DT4 4.9 33.7 1.0 C5 A:DC6 5.0 28.6 1.0

Copper binding site 2 out of 2 in the Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Copper(II) Bound to A Non-Canonical Quadruplex Containing the Damaged Base 8-Oxoguanine within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu101 b:26.4 occ:0.34 N7 B:DG5 2.2 13.2 1.0 C8 B:DG5 3.1 13.0 1.0 H8 B:DG5 3.2 15.7 1.0 C5 B:DG5 3.2 11.9 1.0 H5'' B:DT4 3.3 21.1 1.0 O6 B:DG5 3.5 13.6 1.0 O B:HOH213 3.5 35.3 0.9 O B:HOH217 3.6 37.5 1.0 C6 B:DG5 3.7 12.1 1.0 H42 B:DC6 3.8 29.5 1.0 H4' B:DA3 3.9 13.8 1.0 H41 B:DC6 4.1 29.5 1.0 N4 B:DC6 4.1 24.6 1.0 C5' B:DT4 4.2 17.6 1.0 H5' B:DT4 4.3 21.1 1.0 OP2 B:DG5 4.3 17.0 1.0 N9 B:DG5 4.3 12.2 1.0 C4 B:DG5 4.4 11.4 1.0 O B:HOH207 4.4 38.4 1.0 O3' B:DA3 4.7 14.6 1.0 C4' B:DA3 4.8 11.5 1.0 H4' B:DT4 4.8 18.9 1.0 H3' B:DT4 5.0 18.5 1.0 C4 B:DC6 5.0 26.4 1.0

M.C.Lambert, J.A.Brazier, C.J.Cardin, J.P.Hall. Oxidative Damage Induce Copper(II)-Dna Binding To Be Published.