Copper in PDB 7ysw: Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex

All present enzymatic activity of Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex:
2.7.10.1; 3.2.1.31;

The structure of Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Copper atom in the Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex (pdb code 7ysw). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex, PDB code: 7ysw:

Copper binding site 1 out of 1 in the Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Cryo-Em Structure of FGF23-FGFR4-Aklotho-Hs Quaternary Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:Cu401 b:159.0 occ:1.00 NE2 E:HIS247 2.2 146.2 1.0 CD2 E:HIS247 2.9 146.2 1.0 CE1 E:HIS247 3.3 146.9 1.0 CD2 C:HIS247 3.4 107.8 1.0 NE2 C:HIS247 3.8 108.2 1.0 CG C:PRO246 4.1 106.5 1.0 CG E:HIS247 4.1 147.0 1.0 CD C:PRO246 4.2 107.7 1.0 CB E:SER245 4.2 151.1 1.0 ND1 E:HIS247 4.3 147.7 1.0 O C:PRO246 4.6 108.7 1.0 CG C:HIS247 4.7 107.0 1.0 CD E:PRO246 4.8 142.0 1.0 N C:PRO246 4.8 109.6 1.0 OD1 E:ASP276 4.9 162.1 1.0

L.Chen, L.Fu, J.Sun, Z.Huang, M.Fang, A.Zinkle, X.Liu, J.Lu, Z.Pan, Y.Wang, G.Liang, X.Li, G.Chen, M.Mohammadi. Structural Basis For Fgf Hormone Signalling Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-06155-9