Atomistry » Copper » PDB 7pyl-7s1d » 7rh5
Atomistry »
  Copper »
    PDB 7pyl-7s1d »
      7rh5 »

Copper in PDB 7rh5: Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free

Enzymatic activity of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free

All present enzymatic activity of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free:
1.15.1.1; 7.1.1.8; 7.1.1.9;

Other elements in 7rh5:

The structure of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free also contains other interesting chemical elements:

Iron (Fe) 16 atoms

Copper Binding Sites:

The binding sites of Copper atom in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free (pdb code 7rh5). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 6 binding sites of Copper where determined in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free, PDB code: 7rh5:
Jump to Copper binding site number: 1; 2; 3; 4; 5; 6;

Copper binding site 1 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 1 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:Cu401

b:72.3
occ:1.00
 SG Q:CYS277 1.8 50.4 1.0
SG Q:CYS273 1.8 51.6 1.0
CE1 Q:HIS281 2.0 50.6 1.0
ND1 Q:HIS281 2.0 50.6 1.0
CE Q:MET284 2.9 51.8 1.0
CB Q:CYS273 2.9 51.6 1.0
CB Q:CYS277 3.3 50.4 1.0
NE2 Q:HIS281 3.3 50.6 1.0
CG Q:HIS281 3.4 50.6 1.0
CB Q:HIS232 3.7 51.5 1.0
SD Q:MET284 3.9 51.8 1.0
CD2 Q:HIS281 4.0 50.6 1.0
C Q:CYS273 4.0 51.6 1.0
CA Q:CYS273 4.0 51.6 1.0
O Q:CYS273 4.2 51.6 1.0
O Q:HIS281 4.2 50.6 1.0
CG Q:HIS232 4.2 51.5 1.0
N Q:THR274 4.4 50.9 1.0
CB Q:HIS281 4.4 50.6 1.0
N Q:GLU275 4.4 50.2 1.0
CD2 Q:HIS232 4.4 51.5 1.0
O Q:GLU275 4.4 50.2 1.0
CA Q:CYS277 4.4 50.4 1.0
CU Q:CU402 4.5 62.0 1.0
N Q:CYS277 4.5 50.4 1.0
CA Q:HIS281 4.5 50.6 1.0
CB Q:MET284 4.6 51.8 1.0
C Q:GLU275 4.7 50.2 1.0
C Q:HIS281 4.8 50.6 1.0
N Q:GLY233 4.8 51.3 1.0
CG Q:MET284 4.9 51.8 1.0
CA Q:GLU275 4.9 50.2 1.0
CA Q:HIS232 4.9 51.5 1.0
CB Q:GLU275 4.9 50.2 1.0
C Q:MET276 5.0 48.1 1.0

Copper binding site 2 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 2 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
Q:Cu402

b:62.0
occ:1.00
 CE1 Q:HIS232 1.9 51.5 1.0
ND1 Q:HIS232 2.0 51.5 1.0
NE2 Q:HIS232 2.0 51.5 1.0
CG Q:HIS232 2.2 51.5 1.0
CD2 Q:HIS232 2.2 51.5 1.0
CE Q:MET284 3.2 51.8 1.0
O Q:PHE136 3.3 53.2 1.0
CB Q:HIS232 3.3 51.5 1.0
SD Q:MET284 3.6 51.8 1.0
SG Q:CYS277 3.7 50.4 1.0
CG1 Q:VAL230 4.1 49.9 1.0
O Q:ALA135 4.1 52.3 1.0
C Q:PHE136 4.2 53.2 1.0
CB Q:CYS277 4.2 50.4 1.0
N Q:TRP138 4.3 51.4 1.0
O Q:VAL230 4.4 49.9 1.0
CU Q:CU401 4.5 72.3 1.0
CA Q:GLN137 4.6 51.4 1.0
C Q:ALA135 4.6 52.3 1.0
SG Q:CYS273 4.6 51.6 1.0
CA Q:HIS232 4.7 51.5 1.0
O Q:ILE231 4.7 50.0 1.0
CB Q:ALA135 4.8 52.3 1.0
N Q:GLN137 4.8 51.4 1.0
N Q:HIS232 4.9 51.5 1.0
NE2 Q:GLN137 5.0 51.4 1.0
C Q:GLN137 5.0 51.4 1.0
C Q:ILE231 5.0 50.0 1.0

Copper binding site 3 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 3 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Cu601

b:95.5
occ:1.00
 CE1 R:HIS313 1.8 52.4 1.0
NE2 R:HIS314 2.0 51.2 1.0
ND1 R:HIS264 2.0 49.1 1.0
NE2 R:HIS313 2.0 52.4 1.0
CE1 R:HIS264 2.3 49.1 1.0
CE1 R:HIS314 2.5 51.2 1.0
ND1 R:HIS313 3.0 52.4 1.0
CD2 R:HIS314 3.0 51.2 1.0
CG R:HIS264 3.2 49.1 1.0
CD2 R:HIS313 3.3 52.4 1.0
NE2 R:HIS264 3.5 49.1 1.0
ND1 R:HIS314 3.6 51.2 1.0
NA R:HEA603 3.7 51.2 1.0
CG R:HIS313 3.7 52.4 1.0
CG R:HIS314 3.9 51.2 1.0
CD2 R:HIS264 4.0 49.1 1.0
C4A R:HEA603 4.0 51.2 1.0
C1A R:HEA603 4.0 51.2 1.0
CB R:HIS264 4.0 49.1 1.0
FE R:HEA603 4.1 51.2 1.0
CHB R:HEA603 4.4 51.2 1.0
NB R:HEA603 4.5 51.2 1.0
C3A R:HEA603 4.5 51.2 1.0
CHA R:HEA603 4.5 51.2 1.0
ND R:HEA603 4.6 51.2 1.0
C2A R:HEA603 4.6 51.2 1.0
C1B R:HEA603 4.6 51.2 1.0
CA R:HIS264 4.7 49.1 1.0
C4D R:HEA603 4.7 51.2 1.0
O R:VAL310 4.8 50.3 1.0
O R:TRP311 4.9 49.3 1.0
CG2 R:VAL267 5.0 47.8 1.0

Copper binding site 4 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 4 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 4 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cu401

b:74.4
occ:1.00
 SG K:CYS273 1.8 55.0 1.0
SG K:CYS277 1.8 55.5 1.0
ND1 K:HIS281 2.0 54.4 1.0
CE1 K:HIS281 2.2 54.4 1.0
CB K:CYS273 3.0 55.0 1.0
CB K:CYS277 3.1 55.5 1.0
SD K:MET284 3.3 56.4 1.0
CG K:HIS281 3.4 54.4 1.0
NE2 K:HIS281 3.5 54.4 1.0
CB K:HIS232 3.5 56.0 1.0
N K:CYS277 3.6 55.5 1.0
CA K:CYS277 3.9 55.5 1.0
CE K:MET284 4.0 56.4 1.0
CD2 K:HIS281 4.0 54.4 1.0
CA K:CYS273 4.1 55.0 1.0
C K:MET276 4.2 52.4 1.0
CU K:CU402 4.2 83.4 1.0
CG K:HIS232 4.2 56.0 1.0
O K:HIS281 4.2 54.4 1.0
CB K:HIS281 4.3 54.4 1.0
C K:CYS273 4.3 55.0 1.0
O K:GLU275 4.3 54.1 1.0
C K:GLU275 4.4 54.1 1.0
CA K:HIS281 4.4 54.4 1.0
N K:GLU275 4.4 54.1 1.0
O K:CYS273 4.5 55.0 1.0
CG K:MET284 4.6 56.4 1.0
CD2 K:HIS232 4.6 56.0 1.0
N K:THR274 4.7 54.1 1.0
CA K:MET276 4.7 52.4 1.0
N K:MET276 4.7 52.4 1.0
CB K:GLU275 4.7 54.1 1.0
CB K:MET284 4.7 56.4 1.0
O K:MET276 4.8 52.4 1.0
CA K:GLU275 4.8 54.1 1.0
CA K:HIS232 4.8 56.0 1.0
C K:HIS281 4.8 54.4 1.0
N K:GLY233 4.9 55.6 1.0
ND1 K:HIS232 5.0 56.0 1.0

Copper binding site 5 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 5 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 5 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
K:Cu402

b:83.4
occ:1.00
 CD2 K:HIS232 1.4 56.0 1.0
NE2 K:HIS232 1.9 56.0 1.0
CG K:HIS232 2.3 56.0 1.0
SG K:CYS277 2.6 55.5 1.0
CE1 K:HIS232 2.7 56.0 1.0
ND1 K:HIS232 2.9 56.0 1.0
CB K:CYS277 3.1 55.5 1.0
CB K:HIS232 3.3 56.0 1.0
CE K:MET284 3.3 56.4 1.0
SD K:MET284 3.4 56.4 1.0
O K:PHE136 3.5 57.7 1.0
CG1 K:VAL230 3.8 55.0 1.0
CA K:CYS277 3.8 55.5 1.0
CU K:CU401 4.2 74.4 1.0
OE1 K:GLN137 4.2 56.7 1.0
O K:ILE231 4.3 54.6 1.0
N K:TRP138 4.3 56.2 1.0
C K:PHE136 4.4 57.7 1.0
SG K:CYS273 4.6 55.0 1.0
O K:VAL230 4.6 55.0 1.0
CA K:GLN137 4.6 56.7 1.0
CA K:HIS232 4.6 56.0 1.0
O K:CYS277 4.7 55.5 1.0
C K:CYS277 4.8 55.5 1.0
C K:ILE231 4.8 54.6 1.0
N K:CYS277 4.8 55.5 1.0
N K:HIS232 4.8 56.0 1.0
N K:GLN137 4.9 56.7 1.0
O K:ALA135 5.0 56.8 1.0

Copper binding site 6 out of 6 in 7rh5

Go back to Copper Binding Sites List in 7rh5
Copper binding site 6 out of 6 in the Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 6 of Mycobacterial CIII2CIV2 Supercomplex, Inhibitor Free within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Cu601

b:84.9
occ:1.00
 CE1 L:HIS313 1.8 55.5 1.0
NE2 L:HIS314 2.0 54.2 1.0
NE2 L:HIS313 2.0 55.5 1.0
CE1 L:HIS314 2.6 54.2 1.0
ND1 L:HIS264 2.8 51.6 1.0
ND1 L:HIS313 3.0 55.5 1.0
CD2 L:HIS314 3.0 54.2 1.0
CG L:HIS264 3.1 51.6 1.0
CE1 L:HIS264 3.1 51.6 1.0
CD2 L:HIS313 3.2 55.5 1.0
CD2 L:HIS264 3.5 51.6 1.0
NE2 L:HIS264 3.6 51.6 1.0
CG L:HIS313 3.7 55.5 1.0
ND1 L:HIS314 3.7 54.2 1.0
CB L:HIS264 3.7 51.6 1.0
CG L:HIS314 3.9 54.2 1.0
NA L:HEA603 4.1 53.6 1.0
C1A L:HEA603 4.3 53.6 1.0
FE L:HEA603 4.4 53.6 1.0
C4A L:HEA603 4.4 53.6 1.0
CA L:HIS264 4.5 51.6 1.0
O L:VAL310 4.6 53.9 1.0
CHA L:HEA603 4.6 53.6 1.0
ND L:HEA603 4.7 53.6 1.0
O L:TRP311 4.8 53.2 1.0
C4D L:HEA603 4.8 53.6 1.0
C2A L:HEA603 4.8 53.6 1.0
C3A L:HEA603 4.9 53.6 1.0
CHB L:HEA603 5.0 53.6 1.0
NB L:HEA603 5.0 53.6 1.0

Reference:

D.J.Yanofsky, J.M.Di Trani, S.Krol, R.Abdelaziz, S.A.Bueler, P.Imming, P.Brzezinski, J.L.Rubinstein. Structure of Mycobacterial CIII2CIV2 Respiratory Supercomplex Bound to the Tuberculosis Drug Candidate Telacebec (Q203) To Be Published.
Page generated: Wed Jul 31 09:03:11 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy