Copper in PDB 7o37: Murine Supercomplex CIII2CIV in the Assembled Locked Conformation

All present enzymatic activity of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation:
7.1.1.8; 7.1.1.9;

The structure of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation also contains other interesting chemical elements:

Iron	(Fe)	12 atoms
Sodium	(Na)	1 atom
Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom

The binding sites of Copper atom in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation (pdb code 7o37). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 3 binding sites of Copper where determined in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation, PDB code: 7o37:
Jump to Copper binding site number: 1; 2; 3;

Copper binding site 1 out of 3 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ a:Cu601 b:22.9 occ:1.00 NE2 a:HIS291 2.0 16.6 1.0 ND1 a:HIS240 2.0 21.0 1.0 NE2 a:HIS290 2.1 22.7 1.0 CE1 a:HIS291 2.6 14.2 1.0 CE1 a:HIS240 2.8 25.7 1.0 CE1 a:HIS290 2.9 18.8 1.0 CD2 a:HIS290 3.1 24.4 1.0 CD2 a:HIS291 3.1 11.5 1.0 CG a:HIS240 3.2 19.0 1.0 CB a:HIS240 3.7 13.3 1.0 ND1 a:HIS291 3.8 12.6 1.0 NE2 a:HIS240 4.0 26.1 1.0 ND1 a:HIS290 4.1 15.6 1.0 CG a:HIS291 4.1 11.6 1.0 NA a:HEA604 4.1 12.5 1.0 CG a:HIS290 4.2 15.5 1.0 CD2 a:HIS240 4.2 22.3 1.0 FE a:HEA604 4.3 20.7 1.0 C4A a:HEA604 4.4 15.4 1.0 C1A a:HEA604 4.4 10.7 1.0 CA a:HIS240 4.4 15.9 1.0 NB a:HEA604 4.7 22.9 1.0 ND a:HEA604 4.7 14.0 1.0 CHB a:HEA604 4.8 21.6 1.0 CHA a:HEA604 4.8 9.1 1.0 CG2 a:VAL243 4.8 55.6 1.0 C1B a:HEA604 4.9 27.0 1.0 O a:VAL287 4.9 28.6 1.0 C4D a:HEA604 4.9 10.9 1.0 C3A a:HEA604 5.0 13.6 1.0

Copper binding site 2 out of 3 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ b:Cu303 b:92.3 occ:1.00 CU1 b:CUA303 0.0 92.3 1.0 ND1 b:HIS161 2.3 51.1 1.0 SG b:CYS200 2.3 57.0 1.0 SD b:MET207 2.4 33.1 1.0 CE b:MET207 2.4 149.9 1.0 SG b:CYS196 2.4 56.1 1.0 CU2 b:CUA303 2.5 25.1 1.0 CE1 b:HIS161 3.1 44.2 1.0 CG b:HIS161 3.3 34.6 1.0 CB b:CYS196 3.3 16.5 1.0 CB b:CYS200 3.4 19.6 1.0 CB b:HIS161 3.7 17.3 1.0 CG b:MET207 3.8 35.8 1.0 CA b:HIS161 4.1 13.8 1.0 O b:GLU198 4.2 20.3 1.0 NE2 b:HIS161 4.3 36.7 1.0 ND1 b:HIS204 4.3 32.4 1.0 CD2 b:HIS161 4.4 31.5 1.0 CA b:CYS196 4.8 14.4 1.0 CA b:CYS200 4.8 12.7 1.0 O b:LEU160 4.8 29.9 1.0 N b:SER162 4.8 13.1 1.0 CE1 b:HIS204 4.9 36.6 1.0 CZ2 b:TRP106 4.9 13.2 1.0

Copper binding site 3 out of 3 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ b:Cu303 b:25.1 occ:1.00 CU2 b:CUA303 0.0 25.1 1.0 ND1 b:HIS204 1.9 32.4 1.0 SG b:CYS200 2.2 57.0 1.0 SG b:CYS196 2.3 56.1 1.0 CU1 b:CUA303 2.5 92.3 1.0 CE1 b:HIS204 2.5 36.6 1.0 O b:GLU198 2.5 20.3 1.0 CG b:HIS204 3.1 27.9 1.0 CB b:CYS196 3.1 16.5 1.0 CB b:CYS200 3.5 19.6 1.0 O b:HIS204 3.6 15.3 1.0 NE2 b:HIS204 3.7 31.3 1.0 C b:GLU198 3.7 16.8 1.0 CB b:HIS204 3.8 21.5 1.0 N b:CYS200 3.9 11.1 1.0 CA b:HIS204 3.9 11.1 1.0 CE b:MET207 4.0 149.9 1.0 CD2 b:HIS204 4.0 26.1 1.0 SD b:MET207 4.2 33.1 1.0 C b:HIS204 4.2 12.3 1.0 C b:CYS196 4.3 36.3 1.0 CA b:CYS200 4.3 12.7 1.0 CA b:CYS196 4.3 14.4 1.0 O b:CYS196 4.3 56.0 1.0 N b:GLU198 4.4 21.2 1.0 C b:ILE199 4.4 11.7 1.0 ND1 b:HIS161 4.5 51.1 1.0 CA b:ILE199 4.6 14.5 1.0 N b:ILE199 4.6 15.4 1.0 CA b:GLU198 4.7 22.1 1.0 CG b:MET207 4.7 35.8 1.0 N b:SER197 4.7 25.3 1.0

I.Vercellino, L.A.Sazanov. Structure and Assembly of the Mammalian Mitochondrial Supercomplex CIII2CIV Nature 2021.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-021-03927-Z