Copper in PDB 7l5c: Structure of Copper Bound MEMO1

The structure of Structure of Copper Bound MEMO1, PDB code: 7l5c was solved by M.T.Boniecki, E.E.Uhlemann, O.Y.Dmitriev, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.91 / 2.55
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	140.63, 87.16, 98.59, 90, 90, 90
R / Rfree (%)	18.9 / 24.7

The binding sites of Copper atom in the Structure of Copper Bound MEMO1 (pdb code 7l5c). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 4 binding sites of Copper where determined in the Structure of Copper Bound MEMO1, PDB code: 7l5c:
Jump to Copper binding site number: 1; 2; 3; 4;

Copper binding site 1 out of 4 in the Structure of Copper Bound MEMO1


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Structure of Copper Bound MEMO1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu303 b:67.3 occ:0.49 SG A:CYS244 2.4 37.7 1.0 NE2 A:HIS49 2.7 30.2 1.0 NE2 A:HIS81 2.9 47.8 1.0 CB A:CYS244 3.1 30.6 1.0 CE1 A:HIS49 3.5 28.9 1.0 CE1 A:HIS81 3.7 44.1 1.0 CD2 A:HIS49 3.8 28.9 1.0 CD2 A:HIS81 3.9 39.6 1.0 NE2 A:HIS192 3.9 34.4 1.0 O A:HOH416 3.9 40.9 1.0 CE1 A:HIS192 4.0 33.6 1.0 OD2 A:ASP189 4.2 40.0 1.0 CA A:CYS244 4.6 37.6 1.0 CG A:ASP189 4.7 36.0 1.0 CB A:ASP189 4.7 27.6 1.0 ND1 A:HIS49 4.8 31.1 1.0 ND1 A:HIS81 4.8 37.9 1.0 CG A:HIS49 4.9 34.8 1.0 CG A:HIS81 4.9 43.3 1.0

Copper binding site 2 out of 4 in the Structure of Copper Bound MEMO1


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Structure of Copper Bound MEMO1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu304 b:60.1 occ:0.40 SG B:CYS244 2.4 42.9 1.0 NE2 B:HIS81 2.6 56.8 1.0 NE2 B:HIS49 2.8 42.0 1.0 CB B:CYS244 3.0 30.8 1.0 CE1 B:HIS81 3.4 42.4 1.0 CE1 B:HIS49 3.6 43.1 1.0 O B:HOH415 3.6 47.5 1.0 CD2 B:HIS81 3.7 50.9 1.0 CD2 B:HIS49 3.8 35.2 1.0 NE2 B:HIS192 4.1 39.9 1.0 OD2 B:ASP189 4.2 46.2 1.0 CE1 B:HIS192 4.2 42.2 1.0 CA B:CYS244 4.5 39.1 1.0 ND1 B:HIS81 4.6 48.4 1.0 CB B:ASP189 4.7 40.0 1.0 CG B:HIS81 4.7 51.6 1.0 CG B:ASP189 4.7 47.4 1.0 ND1 B:HIS49 4.8 43.1 1.0 CG B:HIS49 4.9 47.4 1.0

Copper binding site 3 out of 4 in the Structure of Copper Bound MEMO1


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Structure of Copper Bound MEMO1 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cu309 b:73.0 occ:0.58 SG C:CYS244 2.8 47.4 1.0 NE2 C:HIS49 3.1 44.7 1.0 O C:HOH419 3.1 33.2 1.0 NE2 C:HIS81 3.1 53.6 1.0 CB C:CYS244 3.3 37.2 1.0 CE1 C:HIS81 3.5 53.5 1.0 NE2 C:HIS192 3.6 35.3 1.0 CE1 C:HIS192 3.8 31.1 1.0 CD2 C:HIS49 4.0 32.7 1.0 CE1 C:HIS49 4.1 30.0 1.0 OD2 C:ASP189 4.1 31.9 1.0 CD2 C:HIS81 4.2 52.9 1.0 ND1 C:HIS81 4.6 46.6 1.0 CD2 C:HIS192 4.7 30.9 1.0 CB C:ASP189 4.7 31.2 1.0 CG C:ASP189 4.7 41.0 1.0 CA C:CYS244 4.8 31.1 1.0 ND1 C:HIS192 4.9 36.3 1.0

Copper binding site 4 out of 4 in the Structure of Copper Bound MEMO1


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 4 of Structure of Copper Bound MEMO1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cu305 b:119.5 occ:1.00 O D:HOH419 3.1 43.6 1.0 NE2 D:HIS49 3.1 47.5 1.0 SG D:CYS244 3.3 48.0 1.0 NE2 D:HIS192 3.3 49.4 1.0 NE2 D:HIS81 3.5 54.5 1.0 OD2 D:ASP189 3.6 46.3 1.0 CD2 D:HIS49 3.7 35.6 1.0 CE1 D:HIS192 3.9 43.4 1.0 CB D:CYS244 4.1 31.7 1.0 CE1 D:HIS81 4.1 52.3 1.0 CE1 D:HIS49 4.2 40.2 1.0 CG D:ASP189 4.2 47.6 1.0 CB D:ASP189 4.2 40.0 1.0 CD2 D:HIS81 4.4 56.1 1.0 CD2 D:HIS192 4.5 42.5 1.0 CE1 D:HIS131 4.8 52.7 1.0 CG D:HIS49 5.0 46.1 1.0

N.V.Dolgova, E.E.Uhlemann, M.T.Boniecki, F.S.Vizeacoumar, F.J.Vizeacoumar, O.Y.Dmitriev. MEMO1 Is An Iron Containing Regulator of Metal Homeostasis in the Cell To Be Published.