Copper in PDB 6t15: The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae

All present enzymatic activity of The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae:
1.9.3.1; 7.1.1.8;

The structure of The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom
Iron	(Fe)	12 atoms

The binding sites of Copper atom in the The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae (pdb code 6t15). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 3 binding sites of Copper where determined in the The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae, PDB code: 6t15:
Jump to Copper binding site number: 1; 2; 3;

Copper binding site 1 out of 3 in the The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ a:Cu601 b:0.8 occ:1.00 ND1 a:HIS241 2.2 0.1 1.0 NE2 a:HIS290 2.2 0.6 1.0 NE2 a:HIS291 2.2 0.7 1.0 CE1 a:HIS291 2.4 0.7 1.0 CG a:HIS241 2.9 0.1 1.0 CE1 a:HIS290 3.0 0.6 1.0 CB a:HIS241 3.0 0.1 1.0 CD2 a:HIS290 3.2 0.6 1.0 CE1 a:HIS241 3.2 0.1 1.0 CD2 a:HIS291 3.5 0.7 1.0 CA a:HIS241 3.6 0.1 1.0 ND1 a:HIS291 3.7 0.7 1.0 CD2 a:HIS241 4.1 0.1 1.0 ND1 a:HIS290 4.2 0.6 1.0 CG a:HIS291 4.2 0.7 1.0 NE2 a:HIS241 4.2 0.1 1.0 CG a:HIS290 4.3 0.6 1.0 N a:HIS241 4.4 0.1 1.0 O a:GLY240 4.7 0.9 1.0 CHD a:HEA603 4.7 0.9 1.0 C1D a:HEA603 4.8 0.9 1.0 ND a:HEA603 4.8 0.9 1.0 C a:HIS241 4.8 0.1 1.0 C a:GLY240 4.9 0.9 1.0 FE a:HEA603 4.9 0.9 1.0 C4C a:HEA603 4.9 0.9 1.0 O a:HIS241 4.9 0.1 1.0 NC a:HEA603 4.9 0.9 1.0

Copper binding site 2 out of 3 in the The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ b:Cu301 b:0.7 occ:1.00 CU1 b:CUA301 0.0 0.7 1.0 CE b:MET232 1.9 0.0 1.0 ND1 b:HIS186 2.1 0.6 1.0 SG b:CYS225 2.2 0.7 1.0 SD b:MET232 2.3 0.0 1.0 SG b:CYS221 2.3 0.9 1.0 CU2 b:CUA301 2.6 0.9 1.0 CE1 b:HIS186 2.9 0.6 1.0 CG b:HIS186 3.1 0.6 1.0 CB b:CYS221 3.4 0.9 1.0 CB b:HIS186 3.6 0.6 1.0 CB b:CYS225 3.6 0.7 1.0 CG b:MET232 3.8 0.0 1.0 NE2 b:HIS186 4.0 0.6 1.0 CD2 b:HIS186 4.1 0.6 1.0 CA b:HIS186 4.2 0.6 1.0 O b:GLU223 4.4 0.7 1.0 CB b:MET232 4.5 0.0 1.0 ND1 b:HIS229 4.6 0.8 1.0 CA b:CYS221 4.8 0.9 1.0 CZ2 b:TRP126 4.8 0.3 1.0 N b:ASP187 4.9 0.4 1.0 CA b:CYS225 4.9 0.7 1.0

Copper binding site 3 out of 3 in the The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of The III2-IV(5B)1 Respiratory Supercomplex From S. Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ b:Cu301 b:0.9 occ:1.00 CU2 b:CUA301 0.0 0.9 1.0 ND1 b:HIS229 2.1 0.8 1.0 SG b:CYS221 2.2 0.9 1.0 SG b:CYS225 2.2 0.7 1.0 O b:GLU223 2.5 0.7 1.0 CE1 b:HIS229 2.6 0.8 1.0 CU1 b:CUA301 2.6 0.7 1.0 CB b:CYS221 3.0 0.9 1.0 CG b:HIS229 3.4 0.8 1.0 CB b:CYS225 3.5 0.7 1.0 C b:GLU223 3.7 0.7 1.0 N b:CYS225 3.8 0.7 1.0 NE2 b:HIS229 3.9 0.8 1.0 SD b:MET232 3.9 0.0 1.0 CA b:HIS229 4.0 0.8 1.0 CB b:HIS229 4.1 0.8 1.0 O b:HIS229 4.1 0.8 1.0 ND1 b:HIS186 4.2 0.6 1.0 CE b:MET232 4.2 0.0 1.0 CD2 b:HIS229 4.2 0.8 1.0 CA b:CYS225 4.3 0.7 1.0 CA b:CYS221 4.3 0.9 1.0 C b:LEU224 4.3 0.9 1.0 C b:CYS221 4.3 0.9 1.0 N b:GLU223 4.3 0.7 1.0 O b:CYS221 4.4 0.9 1.0 CA b:LEU224 4.5 0.9 1.0 N b:LEU224 4.6 0.9 1.0 C b:HIS229 4.6 0.8 1.0 CA b:GLU223 4.6 0.7 1.0 N b:SER222 4.8 0.7 1.0 CE1 b:HIS186 4.9 0.6 1.0

A.M.Hartley, B.Meunier, N.Pinotsis, A.Marechal. RCF2 Revealed in Cryo-Em Structures of Hypoxic Isoforms of Mature Mitochondrial III-IV Supercomplexes. Proc.Natl.Acad.Sci.Usa 2020.
ISSN: ESSN 1091-6490
PubMed: 32291341
DOI: 10.1073/PNAS.1920612117