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Copper in PDB 6els: Structure of Latent Apple Tyrosinase (MDPPO1)

Protein crystallography data

The structure of Structure of Latent Apple Tyrosinase (MDPPO1), PDB code: 6els was solved by I.Kampatsikas, A.Bijelic, M.Pretzler, A.Rompel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.45 / 1.35
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 50.700, 80.150, 115.960, 90.00, 90.00, 90.00
R / Rfree (%) 14.3 / 17.9

Copper Binding Sites:

The binding sites of Copper atom in the Structure of Latent Apple Tyrosinase (MDPPO1) (pdb code 6els). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Structure of Latent Apple Tyrosinase (MDPPO1), PDB code: 6els:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in 6els

Go back to Copper Binding Sites List in 6els
Copper binding site 1 out of 2 in the Structure of Latent Apple Tyrosinase (MDPPO1)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Structure of Latent Apple Tyrosinase (MDPPO1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu601

b:20.8
occ:0.21
NE2 A:HIS86 1.9 28.9 1.0
NE2 A:HIS116 2.3 16.0 1.0
NE2 A:HIS107 2.4 24.6 1.0
O A:O603 2.5 21.6 1.0
CD2 A:HIS86 2.6 32.7 1.0
CE1 A:HIS116 2.9 15.7 1.0
CE1 A:HIS86 3.1 31.8 1.0
CE1 A:HIS107 3.2 25.3 1.0
CD2 A:HIS116 3.4 12.5 1.0
CD2 A:HIS107 3.5 23.8 1.0
SG A:CYS90 3.7 61.9 1.0
CG A:HIS86 3.8 33.7 1.0
NE2 A:HIS272 3.9 16.3 1.0
CZ A:PHE268 4.0 13.8 1.0
ND1 A:HIS86 4.0 32.4 1.0
CU A:CU602 4.1 17.7 0.2
ND1 A:HIS116 4.1 12.6 1.0
CE1 A:HIS272 4.2 15.7 1.0
CE2 A:PHE268 4.3 12.5 1.0
ND1 A:HIS107 4.4 26.4 1.0
CG A:HIS116 4.4 10.2 1.0
CG A:HIS107 4.5 21.9 1.0
CD1 A:ILE106 4.5 28.5 1.0
CD1 A:PHE259 4.8 21.4 1.0
CE1 A:PHE112 4.9 10.4 1.0
CE1 A:PHE259 4.9 22.7 1.0
CD2 A:HIS272 4.9 13.8 1.0

Copper binding site 2 out of 2 in 6els

Go back to Copper Binding Sites List in 6els
Copper binding site 2 out of 2 in the Structure of Latent Apple Tyrosinase (MDPPO1)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Structure of Latent Apple Tyrosinase (MDPPO1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu602

b:17.7
occ:0.22
O A:O603 1.9 21.6 1.0
NE2 A:HIS238 2.0 14.4 1.0
NE2 A:HIS242 2.1 13.0 1.0
NE2 A:HIS272 2.2 16.3 1.0
CD2 A:HIS238 3.0 10.2 1.0
CE1 A:HIS242 3.0 10.9 1.0
CE1 A:HIS238 3.0 12.3 1.0
CD2 A:HIS242 3.1 11.6 1.0
CE1 A:HIS272 3.1 15.7 1.0
CD2 A:HIS272 3.2 13.8 1.0
CE2 A:PHE268 4.0 12.5 1.0
CD2 A:HIS271 4.0 13.5 1.0
ND1 A:HIS238 4.1 13.1 1.0
ND1 A:HIS272 4.1 12.9 1.0
CG A:HIS238 4.1 10.9 1.0
CU A:CU601 4.1 20.8 0.2
ND1 A:HIS242 4.1 10.4 1.0
CE1 A:PHE259 4.1 22.7 1.0
CG A:HIS242 4.2 9.6 1.0
CG A:HIS272 4.2 11.5 1.0
NE2 A:HIS271 4.3 14.7 1.0
CZ A:PHE268 4.5 13.8 1.0
CD2 A:PHE268 4.6 11.2 1.0
NE2 A:HIS86 4.7 28.9 1.0
CZ A:PHE259 4.8 23.2 1.0
CD1 A:PHE259 4.9 21.4 1.0
CE1 A:PHE112 4.9 10.4 1.0

Reference:

I.Kampatsikas, A.Bijelic, M.Pretzler, A.Rompel. A Peptide-Induced Self-Cleavage Reaction Initiates the Activation of Tyrosinase. Angew.Chem.Int.Ed.Engl. V. 58 7475 2019.
ISSN: ESSN 1521-3773
PubMed: 30825403
DOI: 10.1002/ANIE.201901332
Page generated: Sun Dec 13 11:22:15 2020

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