Copper in PDB 4zfo: J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269)

The structure of J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269), PDB code: 4zfo was solved by S.F.Marino, O.Daumke, D.Olal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.26 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.801, 110.139, 137.279, 90.00, 90.00, 90.00
R / Rfree (%)	17.6 / 20.9

The binding sites of Copper atom in the J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269) (pdb code 4zfo). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 3 binding sites of Copper where determined in the J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269), PDB code: 4zfo:
Jump to Copper binding site number: 1; 2; 3;

Copper binding site 1 out of 3 in the J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269) within 5.0Å range: probe atom residue distance (Å) B Occ L:Cu301 b:16.7 occ:1.00 N L:ASP1 2.0 21.3 1.0 OD1 L:ASP1 2.1 26.5 1.0 CA L:ASP1 2.9 20.0 1.0 CG L:ASP1 3.0 24.4 1.0 O L:HOH563 3.0 43.5 1.0 CB L:ASP1 3.4 22.6 1.0 OD2 L:ASP1 4.0 27.4 1.0 C L:ASP1 4.2 21.2 1.0 O L:ASP1 4.7 20.6 1.0 O L:HOH552 4.7 20.3 1.0

Copper binding site 2 out of 3 in the J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269) within 5.0Å range: probe atom residue distance (Å) B Occ L:Cu302 b:19.1 occ:0.70 O4 L:BTB303 1.9 39.8 1.0 NE2 L:HIS189 1.9 27.6 1.0 N L:BTB303 2.0 35.5 1.0 O3 L:BTB303 2.2 39.4 1.0 O6 L:BTB303 2.2 39.9 1.0 O8 L:BTB303 2.3 29.3 1.0 C2 L:BTB303 2.6 38.7 1.0 C4 L:BTB303 2.7 39.0 1.0 C3 L:BTB303 2.8 39.7 1.0 C7 L:BTB303 2.9 30.8 1.0 CE1 L:HIS189 2.9 27.0 1.0 C6 L:BTB303 2.9 37.7 1.0 C5 L:BTB303 3.0 36.8 1.0 C8 L:BTB303 3.0 28.3 1.0 CD2 L:HIS189 3.0 22.0 1.0 ND1 L:HIS189 4.0 25.1 1.0 C1 L:BTB303 4.1 41.4 1.0 CG L:HIS189 4.1 22.4 1.0 O L:HOH461 4.4 29.8 1.0 OD1 L:ASP185 4.5 30.1 1.0 O1 L:BTB303 4.8 42.4 1.0 O L:HOH479 4.8 38.6 1.0 CB L:LYS188 4.9 20.6 1.0

Copper binding site 3 out of 3 in the J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of J22.9-XI: Chimeric Mouse/Human Antibody Against Human Bcma (CD269) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu301 b:55.8 occ:0.80 N B:BTB302 2.0 81.6 0.8 NE2 B:HIS189 2.1 55.7 1.0 O3 B:BTB302 2.2 82.2 0.8 O8 B:BTB302 2.3 80.4 0.8 CE1 B:HIS189 2.4 58.4 1.0 C2 B:BTB302 2.4 82.1 0.8 O6 B:BTB302 2.4 78.6 0.8 C4 B:BTB302 2.5 80.7 0.8 C3 B:BTB302 2.8 82.2 0.8 C5 B:BTB302 3.0 80.5 0.8 C7 B:BTB302 3.0 81.5 0.8 C8 B:BTB302 3.1 81.1 0.8 C6 B:BTB302 3.2 79.4 0.8 CD2 B:HIS189 3.4 52.8 1.0 O4 B:BTB302 3.6 79.5 0.8 ND1 B:HIS189 3.7 56.9 1.0 C1 B:BTB302 3.9 83.6 0.8 CG B:HIS189 4.2 52.9 1.0 CE B:LYS188 4.4 60.4 1.0 NZ B:LYS188 4.4 63.1 1.0 O1 B:BTB302 4.8 84.7 0.8

F.Oden, S.F.Marino, J.Brand, S.Scheu, C.Kriegel, D.Olal, A.Takvorian, J.Westermann, B.Yilmaz, M.Hinz, O.Daumke, U.E.Hopken, G.Muller, M.Lipp. Potent Anti-Tumor Response By Targeting B Cell Maturation Antigen (Bcma) in A Mouse Model of Multiple Myeloma. Mol Oncol 2015.
ISSN: ISSN 1878-0261
PubMed: 25953704
DOI: 10.1016/J.MOLONC.2015.03.010