Copper in PDB 4yea: Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement

The structure of Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement, PDB code: 4yea was solved by I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.63 / 2.14
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	78.289, 78.289, 54.335, 90.00, 90.00, 120.00
R / Rfree (%)	16 / 19.7

The binding sites of Copper atom in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement (pdb code 4yea). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement, PDB code: 4yea:

Copper binding site 1 out of 1 in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) - New Refinement within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu400 b:39.2 occ:1.00 SG B:CYS15 2.3 33.8 1.0 SG B:CYS12 2.3 37.7 1.0 SG A:CYS12 2.3 39.3 1.0 SG A:CYS15 2.3 36.5 1.0 CB A:CYS12 3.4 38.9 1.0 N B:CYS15 3.6 27.7 1.0 CB B:CYS12 3.6 35.0 1.0 N A:CYS15 3.6 31.3 1.0 CB A:CYS15 3.6 32.5 1.0 CB B:CYS15 3.7 29.1 1.0 N B:CYS12 3.9 32.5 1.0 CA B:CYS15 4.0 27.7 1.0 CA A:CYS15 4.1 31.2 1.0 N A:CYS12 4.1 36.7 1.0 CA B:CYS12 4.2 32.5 1.0 O B:HOH229 4.2 44.8 1.0 CA A:CYS12 4.3 37.0 1.0 OG1 B:THR11 4.3 42.7 1.0 C B:GLY14 4.4 27.9 1.0 OG1 A:THR11 4.4 38.5 1.0 C A:GLY14 4.5 30.3 1.0 O B:CYS12 4.5 27.4 1.0 C B:CYS12 4.6 29.3 1.0 CA B:GLY14 4.6 28.8 1.0 O A:CYS12 4.7 32.8 1.0 C A:CYS12 4.7 34.6 1.0 CA A:GLY14 4.7 30.9 1.0 C A:THR11 4.8 37.8 1.0 C B:THR11 4.8 38.8 1.0 N B:GLY14 4.9 28.6 1.0 N B:THR11 4.9 35.6 1.0 N A:GLY14 5.0 31.0 1.0

I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer. Crystallography and Chemistry Should Always Go Together: A Cautionary Tale of Protein Complexes with Cisplatin and Carboplatin To Be Published.