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Copper in PDB 4oua: Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)

Enzymatic activity of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)

All present enzymatic activity of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI):
1.14.18.1;

Protein crystallography data

The structure of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI), PDB code: 4oua was solved by St.G.Mauracher, C.Molitor, R.Al-Oweini, U.Kortz, A.Rompel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.13 / 2.76
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 213.530, 83.720, 66.950, 90.00, 102.53, 90.00
R / Rfree (%) 18.6 / 22.8

Other elements in 4oua:

The structure of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) also contains other interesting chemical elements:

Tungsten (W) 12 atoms
Tellurium (Te) 2 atoms
Sodium (Na) 4 atoms

Copper Binding Sites:

The binding sites of Copper atom in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) (pdb code 4oua). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 5 binding sites of Copper where determined in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI), PDB code: 4oua:
Jump to Copper binding site number: 1; 2; 3; 4; 5;

Copper binding site 1 out of 5 in 4oua

Go back to Copper Binding Sites List in 4oua
Copper binding site 1 out of 5 in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu401

b:44.3
occ:1.00
NE2 A:HIS57 2.1 34.7 1.0
NE2 A:HIS91 2.1 35.4 1.0
NE2 A:HIS82 2.1 43.8 1.0
O A:HOH549 2.4 42.6 0.9
CD2 A:HIS57 2.9 39.3 1.0
CE1 A:HIS91 3.0 36.9 1.0
CE1 A:HIS82 3.1 49.3 1.0
CD2 A:HIS82 3.1 39.6 1.0
CE1 A:HIS57 3.1 38.6 1.0
CD2 A:HIS91 3.1 32.6 1.0
CB A:CYS80 3.3 40.2 1.0
SG A:CYS80 3.8 48.1 1.0
CG A:HIS57 4.1 43.4 1.0
ND1 A:HIS57 4.1 40.3 1.0
ND1 A:HIS91 4.2 32.3 1.0
ND1 A:HIS82 4.2 42.2 1.0
CU A:CU1402 4.2 30.6 0.9
CG A:HIS82 4.2 40.9 1.0
CG A:HIS91 4.2 34.4 1.0
CE1 A:HIS283 4.3 28.1 1.0
CZ3 A:TRP90 4.4 34.7 1.0
CE1 A:PHE87 4.5 29.7 1.0
CA A:CYS80 4.6 39.0 1.0
CZ A:PHE279 4.6 36.2 1.0
NE2 A:HIS283 4.7 28.6 1.0
CE1 A:PHE279 4.9 36.5 1.0
CE3 A:TRP90 5.0 37.4 1.0

Copper binding site 2 out of 5 in 4oua

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Copper binding site 2 out of 5 in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu402

b:30.6
occ:0.92
CU A:CU1402 0.0 30.6 0.9
NE2 A:HIS283 2.0 28.6 1.0
NE2 A:HIS251 2.0 35.0 1.0
NE2 A:HIS255 2.0 35.9 1.0
CU A:CU1402 2.3 29.3 0.1
O A:HOH549 2.3 42.6 0.9
CE1 A:HIS283 2.5 28.1 1.0
CE1 A:HIS251 2.6 31.6 1.0
CD2 A:HIS255 2.9 38.7 1.0
CE1 A:HIS255 2.9 36.1 1.0
CD2 A:HIS251 3.2 33.2 1.0
CD2 A:HIS283 3.2 36.2 1.0
CE1 A:PHE279 3.7 36.5 1.0
ND1 A:HIS283 3.8 24.9 1.0
ND1 A:HIS251 3.9 29.3 1.0
ND1 A:HIS255 4.0 35.7 1.0
CG A:HIS255 4.0 37.3 1.0
CG A:HIS283 4.2 27.3 1.0
CG A:HIS251 4.2 28.8 1.0
CU A:CU1401 4.2 44.3 1.0
CZ A:PHE279 4.4 36.2 1.0
ND1 A:HIS282 4.4 29.4 1.0
CD1 A:PHE279 4.5 37.9 1.0
CE1 A:HIS282 4.5 23.2 1.0
NE2 A:HIS57 4.6 34.7 1.0
NE2 A:HIS91 4.9 35.4 1.0
CE1 A:HIS57 5.0 38.6 1.0

Copper binding site 3 out of 5 in 4oua

Go back to Copper Binding Sites List in 4oua
Copper binding site 3 out of 5 in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu402

b:29.3
occ:0.08
CU A:CU1402 0.0 29.3 0.1
NE2 A:HIS255 2.1 35.9 1.0
NE2 A:HIS251 2.1 35.0 1.0
NE2 A:HIS283 2.1 28.6 1.0
ND1 A:HIS282 2.2 29.4 1.0
CU A:CU1402 2.3 30.6 0.9
CE1 A:HIS282 2.4 23.2 1.0
CD2 A:HIS251 2.4 33.2 1.0
CD2 A:HIS283 2.7 36.2 1.0
CD2 A:HIS255 2.8 38.7 1.0
CE1 A:HIS283 3.0 28.1 1.0
CE1 A:HIS255 3.0 36.1 1.0
CE1 A:HIS251 3.4 31.6 1.0
CG A:HIS282 3.4 27.8 1.0
NE2 A:HIS282 3.5 24.4 1.0
CG A:HIS251 3.7 28.8 1.0
CG A:HIS283 3.7 27.3 1.0
ND1 A:HIS283 3.8 24.9 1.0
CG A:HIS255 3.9 37.3 1.0
ND1 A:HIS255 4.0 35.7 1.0
CD2 A:HIS282 4.0 22.8 1.0
ND1 A:HIS251 4.1 29.3 1.0
O A:HIS251 4.1 37.3 1.0
CB A:HIS282 4.3 32.8 1.0
O A:HOH549 4.5 42.6 0.9
CE1 A:PHE279 4.6 36.5 1.0
CG2 A:VAL286 4.7 25.8 1.0
CD1 A:PHE279 4.8 37.9 1.0
CB A:HIS251 4.9 26.9 1.0
N A:HIS283 4.9 26.6 1.0
CB A:HIS283 4.9 26.6 1.0
C A:HIS251 4.9 33.7 1.0

Copper binding site 4 out of 5 in 4oua

Go back to Copper Binding Sites List in 4oua
Copper binding site 4 out of 5 in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 4 of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cu601

b:43.4
occ:1.00
NE2 B:HIS57 2.0 38.2 1.0
NE2 B:HIS91 2.0 37.4 1.0
NE2 B:HIS82 2.0 46.6 1.0
O B:HOH780 2.3 32.9 0.9
CD2 B:HIS57 2.9 37.5 1.0
CE1 B:HIS82 2.9 46.2 1.0
CE1 B:HIS91 2.9 36.2 1.0
CD2 B:HIS82 3.1 42.7 1.0
CE1 B:HIS57 3.1 34.9 1.0
CD2 B:HIS91 3.1 34.9 1.0
CB B:CYS80 3.2 32.0 1.0
SG B:CYS80 3.6 48.9 1.0
ND1 B:HIS82 4.0 42.4 1.0
CG B:HIS57 4.0 31.6 1.0
ND1 B:HIS91 4.1 32.6 1.0
ND1 B:HIS57 4.1 36.0 1.0
CG B:HIS82 4.1 43.3 1.0
CG B:HIS91 4.2 30.7 1.0
CZ3 B:TRP90 4.4 27.3 1.0
CA B:CYS80 4.5 32.5 1.0
CE1 B:HIS283 4.6 27.1 1.0
CU B:CU1602 4.7 37.0 1.0
CE1 B:PHE87 4.8 34.8 1.0
NE2 B:HIS283 4.8 36.9 1.0
CZ B:PHE279 4.9 30.9 1.0
C B:CYS80 4.9 33.3 1.0
CE3 B:TRP90 4.9 24.6 1.0
N B:THR81 4.9 33.8 1.0

Copper binding site 5 out of 5 in 4oua

Go back to Copper Binding Sites List in 4oua
Copper binding site 5 out of 5 in the Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 5 of Coexistent Single-Crystal Structure of Latent and Active Mushroom Tyrosinase (ABPPO4) Mediated By A Hexatungstotellurate(VI) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cu602

b:37.0
occ:1.00
NE2 B:HIS255 1.9 30.9 1.0
NE2 B:HIS283 2.0 36.9 1.0
NE2 B:HIS251 2.0 33.6 1.0
O B:HOH780 2.3 32.9 0.9
CE1 B:HIS283 2.5 27.1 1.0
CE1 B:HIS255 2.6 36.1 1.0
CE1 B:HIS251 2.9 34.6 1.0
CD2 B:HIS255 3.1 37.6 1.0
CD2 B:HIS251 3.1 30.2 1.0
CD2 B:HIS283 3.2 30.3 1.0
CE2 B:PHE279 3.7 32.8 1.0
ND1 B:HIS283 3.7 24.4 1.0
ND1 B:HIS255 3.8 38.3 1.0
CZ B:PHE279 4.0 30.9 1.0
CG B:HIS283 4.0 26.2 1.0
ND1 B:HIS251 4.0 26.0 1.0
CG B:HIS255 4.1 34.2 1.0
CD2 B:HIS282 4.1 29.9 1.0
CG B:HIS251 4.2 25.3 1.0
CE2 B:PHE454 4.3 37.4 1.0
NE2 B:HIS282 4.4 29.0 1.0
CD2 B:PHE279 4.5 31.2 1.0
CU B:CU1601 4.7 43.4 1.0
NE2 B:HIS57 4.8 38.2 1.0
CZ B:PHE454 4.8 37.5 1.0
CD2 B:PHE454 4.9 37.6 1.0

Reference:

S.G.Mauracher, C.Molitor, R.Al-Oweini, U.Kortz, A.Rompel. Latent and Active ABPPO4 Mushroom Tyrosinase Cocrystallized with Hexatungstotellurate(VI) in A Single Crystal. Acta Crystallogr.,Sect.D V. 70 2301 2014.
ISSN: ISSN 0907-4449
PubMed: 25195745
DOI: 10.1107/S1399004714013777
Page generated: Sun Dec 13 11:15:29 2020

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