Copper in PDB 4mnt: Crystal Structure of Human Dj-1 in Complex with Cu

The structure of Crystal Structure of Human Dj-1 in Complex with Cu, PDB code: 4mnt was solved by L.Cendron, S.Girotto, M.Bisaglia, I.Tessari, S.Mammi, G.Zanotti, L.Bubacco, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.63 / 1.58
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	75.240, 75.240, 75.300, 90.00, 90.00, 120.00
R / Rfree (%)	15.1 / 17.7

The binding sites of Copper atom in the Crystal Structure of Human Dj-1 in Complex with Cu (pdb code 4mnt). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of Human Dj-1 in Complex with Cu, PDB code: 4mnt:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the Crystal Structure of Human Dj-1 in Complex with Cu


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of Human Dj-1 in Complex with Cu within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu201 b:16.7 occ:0.42 OE2 A:GLU18 2.1 14.5 1.0 SG A:CYS106 2.1 21.4 1.0 O A:HOH304 2.5 23.8 1.0 CD A:GLU18 3.0 13.3 1.0 CB A:CYS106 3.1 13.5 1.0 OE1 A:GLU18 3.2 12.6 1.0 O A:HOH538 3.3 33.3 1.0 CD A:PRO158 3.6 12.1 1.0 O A:HOH418 3.8 28.5 1.0 CG A:GLU15 3.8 11.2 1.0 O A:HOH443 4.0 29.7 1.0 N A:GLY75 4.0 13.2 1.0 CG A:PRO158 4.1 12.1 1.0 CB A:GLU15 4.2 10.2 1.0 CG A:GLU18 4.3 10.8 1.0 CA A:GLY157 4.4 11.4 1.0 N A:PRO158 4.5 9.7 1.0 CA A:CYS106 4.5 14.1 1.0 O A:HOH463 4.5 32.7 1.0 CD2 A:HIS126 4.6 12.6 1.0 CA A:GLY75 4.6 13.6 1.0 C A:GLY74 4.8 9.9 1.0 C A:GLY157 4.8 9.3 1.0 CA A:GLY74 4.9 10.6 1.0 N A:ALA107 4.9 12.0 1.0 CD A:GLU15 4.9 12.7 1.0

Copper binding site 2 out of 2 in the Crystal Structure of Human Dj-1 in Complex with Cu


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of Human Dj-1 in Complex with Cu within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu202 b:25.0 occ:0.22 SG A:CYS53 2.1 32.6 1.0 CB A:CYS53 3.3 18.1 1.0 N A:CYS53 3.8 14.7 1.0 CA A:CYS53 4.0 16.9 1.0 CG A:PRO43 4.0 23.1 1.0 CB A:PRO43 4.1 20.3 1.0 O A:HOH541 4.4 35.0 1.0 CG1 A:VAL51 4.5 15.0 1.0 C A:ILE52 4.5 16.1 1.0 O A:VAL51 4.7 13.4 1.0 CA A:PRO43 4.8 17.5 1.0 O A:ILE52 5.0 16.9 1.0

S.Girotto, L.Cendron, M.Bisaglia, I.Tessari, S.Mammi, G.Zanotti, L.Bubacco. Dj-1 Is A Copper Chaperone Acting on SOD1 Activation. J.Biol.Chem. V. 289 10887 2014.
ISSN: ISSN 0021-9258
PubMed: 24567322
DOI: 10.1074/JBC.M113.535112