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Copper in PDB 4f2f: Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I)

Enzymatic activity of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I)

All present enzymatic activity of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I):
3.6.3.4;

Protein crystallography data

The structure of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I), PDB code: 4f2f was solved by Y.Fu, C.E.Dann Iii, D.P.Giedroc, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.64 / 1.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 35.455, 37.329, 69.294, 90.00, 90.00, 90.00
R / Rfree (%) 21.3 / 24.3

Other elements in 4f2f:

The structure of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Copper Binding Sites:

The binding sites of Copper atom in the Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I) (pdb code 4f2f). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I), PDB code: 4f2f:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in 4f2f

Go back to Copper Binding Sites List in 4f2f
Copper binding site 1 out of 2 in the Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu101

b:17.7
occ:1.00
SG A:CYS86 2.1 14.6 1.0
SG A:CYS49 2.2 15.9 1.0
O A:CYS49 2.2 15.2 1.0
C A:CYS49 3.0 14.0 1.0
CB A:CYS86 3.1 15.1 1.0
CB A:CYS49 3.2 16.3 1.0
CU A:CU1102 3.2 21.3 1.0
CA A:CYS49 3.4 16.1 1.0
CB A:MET88 3.8 16.1 1.0
CB A:MET90 3.9 19.7 1.0
CG A:MET88 4.0 16.0 1.0
CG A:GLN91 4.1 20.7 1.0
N A:GLN91 4.1 18.6 1.0
SD A:MET88 4.1 17.9 1.0
N A:TYR50 4.1 15.5 1.0
N A:MET90 4.4 18.1 1.0
CB A:GLN91 4.4 17.9 1.0
N A:MET88 4.4 17.5 1.0
O A:HOH201 4.5 15.5 1.0
CA A:CYS86 4.5 14.3 1.0
CA A:MET90 4.6 21.4 1.0
CG A:MET90 4.6 21.7 1.0
SD A:MET90 4.6 22.6 1.0
CA A:MET88 4.6 16.2 1.0
CA A:TYR50 4.7 14.3 1.0
C A:MET90 4.8 23.8 1.0
N A:CYS49 4.8 15.6 1.0
CA A:GLN91 4.9 17.7 1.0
C A:CYS86 4.9 14.0 1.0

Copper binding site 2 out of 2 in 4f2f

Go back to Copper Binding Sites List in 4f2f
Copper binding site 2 out of 2 in the Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of the Metal Binding Domain (Mbd) of the Streptococcus Pneumoniae D39 Cu(I) Exporting P-Type Atpase Copa with Cu(I) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu102

b:21.3
occ:1.00
SG A:CYS49 2.2 15.9 1.0
SD A:MET90 2.2 22.6 1.0
SD A:MET88 2.3 17.9 1.0
CL A:CL103 2.5 24.2 0.6
CB A:CYS49 3.2 16.3 1.0
CU A:CU1101 3.2 17.7 1.0
CE A:MET88 3.3 21.4 1.0
CG A:MET90 3.4 21.7 1.0
CE A:MET90 3.4 29.3 1.0
CG A:MET88 3.5 16.0 1.0
CB A:MET88 3.5 16.1 1.0
CA A:CYS49 3.6 16.1 1.0
CB A:MET90 3.7 19.7 1.0
O A:CYS49 4.4 15.2 1.0
C A:CYS49 4.5 14.0 1.0
N A:CYS49 4.8 15.6 1.0
SG A:CYS86 4.9 14.6 1.0

Reference:

Y.Fu, H.C.Tsui, K.E.Bruce, L.T.Sham, K.A.Higgins, J.P.Lisher, K.M.Kazmierczak, M.J.Maroney, C.E.Dann, M.E.Winkler, D.P.Giedroc. A New Structural Paradigm in Copper Resistance in Streptococcus Pneumoniae. Nat.Chem.Biol. V. 9 177 2013.
ISSN: ISSN 1552-4450
PubMed: 23354287
DOI: 10.1038/NCHEMBIO.1168
Page generated: Sun Dec 13 11:14:18 2020

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