Chemical elements
  Copper
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    Cuprous Compounds
    Complex Copper Compounds
    Cupric Compounds
    PDB 1a2v-1bxu
    PDB 1bxv-1fwx
    PDB 1g3d-1j9t
    PDB 1jcv-1mfm
    PDB 1mg2-1paz
    PDB 1pcs-1sii
    PDB 1sjm-1w6w
    PDB 1w77-2afn
    PDB 2ahk-2dv6
    PDB 2dws-2ggp
    PDB 2ghz-2mta
    PDB 2nrd-2vm3
    PDB 2vm4-2yah
    PDB 2yam-3bkt
      2yam
      2yao
      2yap
      2yaq
      2yar
      2yev
      2ygi
      2ygj
      2yx9
      2yxv
      2yxw
      2z7u
      2z7w
      2z7y
      2z7z
      2z8y
      2zcu
      2zcv
      2zhp
      2zkw
      2zkx
      2zl8
      2zmx
      2zmy
      2zmz
      2zon
      2zoo
      2zow
      2ztj
      2ztk
      2zwd
      2zwe
      2zwf
      2zwg
      2zwn
      2zxw
      3aas
      3aau
      3aav
      3abg
      3abk
      3abl
      3abm
      3ag1
      3ag2
      3ag3
      3ag4
      3ala
      3azu
      3bkt
    PDB 3bqv-3fyi
    PDB 3g5w-3mie
    PDB 3mif-3t6v
    PDB 3t6w-9pcy

Copper in the structure of Crystal Structure of The Copper-Bound Tyrosinase In Complex With A Caddie Protein From Streptomyces Castaneoglobisporus Obtained By Soaking the Deoxy-Form Crystal in Dioxygen- Saturated Solution For 5 Minutes (pdb 2zwd)






The binding sites of Copper atom in the structure of Crystal Structure of The Copper-Bound Tyrosinase In Complex With A Caddie Protein From Streptomyces Castaneoglobisporus Obtained By Soaking the Deoxy-Form Crystal in Dioxygen- Saturated Solution For 5 Minutes (pdb code 2zwd). This binding sites where shown with 5.0 Angstroms radius around Copper atom.
The 2zwd structure was solved by Y.MATOBA, M.SUGIYAMA, with X-Ray Crystallography technique, brief refinement statistics is given in the table below:
Resolution (A)30.0-1.4
Space groupP21212
a (A)65.200
b (A)97.830
c (A)55.100
alpha (°)90.00
beta (°)90.00
gamma (°)90.00
Rfactor (%)17.6
Rfree (%)21.7


Copper Binding Sites:

Copper binding site 1 out of 6 in 2zwd


Copper binding site 1 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 1 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: His38, A: Ile42, A: Gly53, A: His54, A: Trp62, A: His63, A: Phe212, A: His216, B: Tyr98, A: Cu1502, A: Cu1503, B: Hoh545,

conact list:


AtomAtomDistance (A)
CuNE2 A:His381.84
CuNE2 A:His382.43
CuND1 A:His383.93
CuND1 A:His384.49
CuCD2 A:His382.78
CuCD2 A:His382.71
CuCE1 A:His382.87
CuCE1 A:His383.72
CuCG A:His383.91
CuCG A:His384.05
CuCD1 A:Ile424.86
CuCG1 A:Ile424.87
CuO A:Gly534.87
CuNE2 A:His542.13
CuND1 A:His544.13
CuCD2 A:His543.16
CuCE1 A:His543.01
CuCG A:His544.22
CuCZ3 A:Trp624.50
CuNE2 A:His632.02
CuND1 A:His633.95
CuCD2 A:His633.22
CuCE1 A:His632.74
CuCG A:His634.22
CuCE2 A:Phe2124.29
CuCZ A:Phe2124.10
CuNE2 A:His2164.32
CuCE1 A:His2164.49
CuOH B:Tyr984.59
CuCU A:Cu15020.00
CuCU A:Cu15022.72
CuCU A:Cu15034.33
CuO B:Hoh5452.51

interactive model:


Copper binding site 2 out of 6 in 2zwd


Copper binding site 2 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 2 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: His38, A: Ile42, A: His54, A: His63, A: His190, A: His194, A: Ser206, A: Phe212, B: Tyr98, A: Cu1502, A: Cu1503, B: Hoh545, B: Hoh796,

conact list:


AtomAtomDistance (A)
CuNE2 A:His382.80
CuNE2 A:His382.31
CuND1 A:His383.73
CuND1 A:His384.05
CuCD2 A:His384.15
CuCD2 A:His383.60
CuCE1 A:His382.45
CuCE1 A:His382.77
CuCG A:His384.58
CuCG A:His384.48
CuCD1 A:Ile423.02
CuCG1 A:Ile423.55
CuNE2 A:His542.80
CuND1 A:His544.63
CuCD2 A:His543.36
CuCE1 A:His543.76
CuCG A:His544.44
CuNE2 A:His634.57
CuCE1 A:His1904.97
CuNE2 A:His1944.54
CuCE1 A:His1944.63
CuOG A:Ser2064.14
CuCE2 A:Phe2124.65
CuCE2 B:Tyr983.30
CuCD2 B:Tyr984.64
CuCZ B:Tyr983.05
CuCE1 B:Tyr984.32
CuOH B:Tyr982.08
CuCU A:Cu15022.72
CuCU A:Cu15020.00
CuCU A:Cu15034.00
CuO B:Hoh5451.93
CuO B:Hoh7964.29

interactive model:


Copper binding site 3 out of 6 in 2zwd


Copper binding site 3 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 3 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 3 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: His63, A: His190, A: His194, A: Phe212, A: His215, A: His216, B: Tyr98, A: Cu1502, B: Hoh545,

conact list:


AtomAtomDistance (A)
CuNE2 A:His634.76
CuNE2 A:His1902.04
CuND1 A:His1904.10
CuCD2 A:His1903.02
CuCE1 A:His1903.00
CuCG A:His1904.15
CuNE2 A:His1941.95
CuND1 A:His1944.05
CuCD2 A:His1943.04
CuCE1 A:His1942.92
CuCG A:His1944.15
CuCE2 A:Phe2123.99
CuCD2 A:Phe2124.61
CuCZ A:Phe2124.68
CuNE2 A:His2154.32
CuCD2 A:His2154.15
CuNE2 A:His2161.97
CuND1 A:His2164.02
CuCD2 A:His2163.04
CuCE1 A:His2162.86
CuCG A:His2164.10
CuCE2 B:Tyr984.18
CuCZ B:Tyr984.42
CuOH B:Tyr984.14
CuCU A:Cu15024.33
CuCU A:Cu15024.00
CuO B:Hoh5452.20

interactive model:


Copper binding site 4 out of 6 in 2zwd


Copper binding site 4 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 4 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 4 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: Pro231, A: Hoh819, A: Hoh969,

conact list:


AtomAtomDistance (A)
CuCG A:Pro2314.50
CuO A:Hoh8192.07
CuO A:Hoh9692.32

interactive model:


Copper binding site 5 out of 6 in 2zwd


Copper binding site 5 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 5 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 5 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: Met43, B: His82, B: Val83, B: Met84, B: Hoh592,

conact list:


AtomAtomDistance (A)
CuO A:Met433.99
CuNE2 B:His822.71
CuND1 B:His824.70
CuND1 B:His823.59
CuCD2 B:His823.16
CuCE1 B:His823.84
CuCE1 B:His823.70
CuCG B:His824.40
CuCG B:His824.92
CuO B:Val834.94
CuCE B:Met844.49
CuO B:Hoh5924.76

interactive model:


Copper binding site 6 out of 6 in 2zwd


Copper binding site 6 out of 6 in 2zwd
Click to enlarge
stereopicture of Copper binding site 6 out of 6 in 2zwd
Click to enlarge
Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 6 of Copper in the PDB 2zwd. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere
Residues shown as a stick model or VDW spheres: A: Ile42, A: Met43, B: His82, B: Val83, B: Met84, B: His97, B: No3505, A: Hoh554,

conact list:


AtomAtomDistance (A)
CuO A:Ile423.27
CuCG2 A:Ile424.82
CuC A:Ile424.13
CuO A:Met434.21
CuN A:Met434.35
CuCB A:Met434.56
CuC A:Met434.24
CuCG A:Met434.62
CuCA A:Met433.67
CuNE2 B:His823.73
CuNE2 B:His821.92
CuND1 B:His823.10
CuND1 B:His823.85
CuCD2 B:His824.69
CuCD2 B:His823.07
CuCE1 B:His822.57
CuCE1 B:His822.68
CuCG B:His824.40
CuCG B:His824.08
CuO B:Val834.89
CuC B:Val834.85
CuN B:Met844.79
CuCB B:Met843.49
CuCE B:Met842.50
CuCE B:Met843.28
CuCG B:Met844.08
CuCG B:Met842.69
CuSD B:Met843.41
CuSD B:Met842.07
CuCA B:Met844.73
CuNE2 B:His974.93
CuNE2 B:His972.19
CuND1 B:His974.01
CuND1 B:His974.22
CuCD2 B:His973.29
CuCE1 B:His973.70
CuCE1 B:His973.04
CuCG B:His974.39
CuO1 B:No35051.32
CuO2 B:No35052.13
CuN B:No35051.96
CuO3 B:No35053.09
CuO A:Hoh5544.78

interactive model:




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