Copper in PDB 2xmk: Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic)

The structure of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic), PDB code: 2xmk was solved by A.Badarau, S.J.Firbank, A.A.Mccarthy, M.J.Banfield, C.Dennison, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.22 / 1.35
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	62.991, 41.709, 55.791, 90.00, 107.49, 90.00
R / Rfree (%)	12.94 / 15.274

The structure of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Sodium	(Na)	1 atom

The binding sites of Copper atom in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) (pdb code 2xmk). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 4 binding sites of Copper where determined in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic), PDB code: 2xmk:
Jump to Copper binding site number: 1; 2; 3; 4;

Copper binding site 1 out of 4 in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu1101 b:9.5 occ:1.00 SG B:CYS2012 2.2 8.2 1.0 SG A:CYS1012 2.2 8.4 1.0 CL A:CL1104 2.4 12.8 0.5 CU B:CU1102 2.6 10.2 1.0 CU A:CU2101 2.7 10.0 1.0 CB B:CYS2012 3.2 6.7 1.0 CB A:CYS1012 3.2 6.9 1.0 O A:HOH3010 4.0 21.7 1.0 CB A:ALA1011 4.3 9.2 1.0 CA A:CYS1012 4.3 7.6 1.0 CA B:CYS2012 4.4 7.0 1.0 CB B:ALA2011 4.4 9.2 1.0 N A:CYS1012 4.4 7.5 1.0 N B:CYS2012 4.4 7.1 1.0 SG B:CYS2015 4.5 8.1 1.0 SG A:CYS1015 4.6 8.0 1.0 C A:ALA1011 4.6 8.1 1.0 C B:ALA2011 4.6 7.8 1.0 CU A:CU2102 4.8 8.2 1.0 O A:ALA1011 4.9 9.3 1.0 O B:HOH3050 4.9 19.5 1.0 O B:ALA2011 4.9 8.7 1.0 CB B:ALA2014 4.9 8.9 1.0 O A:HOH3054 5.0 21.0 1.0

Copper binding site 2 out of 4 in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu1102 b:10.2 occ:1.00 SG B:CYS2015 2.1 8.1 1.0 SG B:CYS2012 2.2 8.2 1.0 CU B:CU1101 2.6 9.5 1.0 CU A:CU2102 3.0 8.2 1.0 CU A:CU2101 3.0 10.0 1.0 N B:CYS2015 3.1 6.2 1.0 CB B:CYS2015 3.1 7.6 1.0 N B:CYS2012 3.2 7.1 1.0 CB B:CYS2012 3.3 6.7 1.0 CA B:CYS2012 3.6 7.0 1.0 O B:CYS2012 3.6 6.5 1.0 CA B:CYS2015 3.6 6.8 1.0 C B:CYS2012 3.8 6.7 1.0 SG A:CYS1012 3.8 8.4 1.0 C B:ALA2011 3.9 7.8 1.0 SG A:CYS1015 3.9 8.0 1.0 CB B:ALA2011 3.9 9.2 1.0 N B:ALA2011 4.0 7.7 1.0 C B:ALA2014 4.1 7.1 1.0 CA B:ALA2011 4.1 7.6 1.0 CB B:ALA2014 4.2 8.9 1.0 N B:ALA2014 4.3 8.0 1.0 CA B:ALA2014 4.4 7.5 1.0 CB A:ALA1014 4.7 10.2 1.0 N B:GLU2013 4.7 7.1 1.0 O B:ALA2011 4.8 8.7 1.0 CL A:CL1104 4.8 12.8 0.5 C B:CYS2015 5.0 6.3 1.0

Copper binding site 3 out of 4 in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 3 of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu2101 b:10.0 occ:1.00 SG A:CYS1015 2.1 8.0 1.0 SG A:CYS1012 2.2 8.4 1.0 CU B:CU1101 2.7 9.5 1.0 CU A:CU2102 3.0 8.2 1.0 CU B:CU1102 3.0 10.2 1.0 N A:CYS1015 3.2 6.6 1.0 N A:CYS1012 3.2 7.5 1.0 CB A:CYS1015 3.2 6.9 1.0 CB A:CYS1012 3.3 6.9 1.0 CA A:CYS1012 3.5 7.6 1.0 O A:CYS1012 3.6 7.1 1.0 CA A:CYS1015 3.7 6.5 1.0 C A:CYS1012 3.7 7.2 1.0 SG B:CYS2012 3.8 8.2 1.0 C A:ALA1011 3.9 8.1 1.0 SG B:CYS2015 3.9 8.1 1.0 CB A:ALA1011 3.9 9.2 1.0 N A:ALA1011 4.0 8.0 1.0 C A:ALA1014 4.1 7.7 1.0 CA A:ALA1011 4.1 7.6 1.0 CB A:ALA1014 4.3 10.2 1.0 N A:ALA1014 4.3 7.6 1.0 CA A:ALA1014 4.4 7.8 1.0 CB B:ALA2014 4.6 8.9 1.0 N A:GLU1013 4.7 7.4 1.0 O A:ALA1011 4.8 9.3 1.0 CL A:CL1104 4.9 12.8 0.5

Copper binding site 4 out of 4 in the Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic)


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 4 of Visualising the Metal-Binding Versatility of Copper Trafficking Sites: ATX1 Side-to-Side (Anaerobic) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu2102 b:8.2 occ:1.00 SG B:CYS2015 2.2 8.1 1.0 SG A:CYS1015 2.2 8.0 1.0 CL A:CL1103 2.4 8.9 1.0 CU A:CU2101 3.0 10.0 1.0 CU B:CU1102 3.0 10.2 1.0 CB A:CYS1015 3.2 6.9 1.0 CB B:CYS2015 3.2 7.6 1.0 CA B:CYS2015 3.3 6.8 1.0 CA A:CYS1015 3.3 6.5 1.0 N A:CYS1015 3.4 6.6 1.0 N B:CYS2015 3.4 6.2 1.0 C B:ALA2014 4.0 7.1 1.0 C A:ALA1014 4.0 7.7 1.0 O B:ALA2014 4.3 8.0 1.0 O A:ALA1014 4.3 8.0 1.0 CB A:ALA1014 4.6 10.2 1.0 CB B:ALA2014 4.6 8.9 1.0 NE2 B:HIS2061 4.6 13.2 1.0 NE2 A:HIS1061 4.6 12.8 1.0 SG A:CYS1012 4.7 8.4 1.0 C B:CYS2015 4.7 6.3 1.0 CU B:CU1101 4.8 9.5 1.0 C A:CYS1015 4.8 6.7 1.0 SG B:CYS2012 4.8 8.2 1.0 CE1 A:HIS1061 4.8 13.8 1.0 CE1 B:HIS2061 4.9 14.0 1.0 CA A:ALA1014 4.9 7.8 1.0 CA B:ALA2014 4.9 7.5 1.0

A.Badarau, S.J.Firbank, A.A.Mccarthy, M.J.Banfield, C.Dennison. Visualizing the Metal-Binding Versatility of Copper Trafficking Sites . Biochemistry V. 49 7798 2010.
ISSN: ISSN 0006-2960
PubMed: 20726513
DOI: 10.1021/BI101064W