Copper in the structure of Crystal Structure Of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) At 1.36 A Resolution (pdb 2vr8)

The binding sites of Copper atom in the structure of Crystal Structure Of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) At 1.36 A Resolution (pdb code 2vr8). This binding sites where shown with 5.0 Angstroms radius around Copper atom. The 2vr8 structure was solved by S.ANTONYUK, X.CAO, S.V.SEETHARAMAN, L.J.WHITSON, A.B.TAYLOR, S.P.HOLLOWAY, R.W.STRANGE, P.A.DOUCETTE, A.TIWARI, L.J.HAYWARD, S.PADUA, J.A.COHLBERG, J.SELVERSTONE VALENTINE, S.S.HASNAIN, P.J.HART, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 30.0-1.4 Space group P1211 a (A) 34.210 b (A) 56.647 c (A) 74.714 alpha (°) 90.00 beta (°) 102.14 gamma (°) 90.00 Rfactor (%) 11.3 Rfree (%) 15.3 Copper Binding Sites: Copper binding site 1 out of 2 in 2vr8 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Copper in the PDB 2vr8. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: His46, A: His48, A: His63, A: Val118, A: His120, A: Zn1157, A: So41159, A: Hoh2265, conact list: Atom Atom Distance (A) Cu O A:His46 4.57 Cu NE2 A:His46 3.94 Cu N A:His46 4.15 Cu CB A:His46 2.76 Cu ND1 A:His46 1.78 Cu CD2 A:His46 3.81 Cu C A:His46 4.57 Cu CE1 A:His46 2.93 Cu CG A:His46 2.59 Cu CA A:His46 4.01 Cu NE2 A:His48 2.11 Cu ND1 A:His48 4.23 Cu CD2 A:His48 2.98 Cu CE1 A:His48 3.16 Cu CG A:His48 4.17 Cu NE2 A:His63 3.68 Cu CD2 A:His63 3.91 Cu CE1 A:His63 4.56 Cu CG A:His63 4.89 Cu O A:Val118 4.46 Cu CB A:Val118 3.95 Cu CG2 A:Val118 4.66 Cu C A:Val118 4.95 Cu CG1 A:Val118 4.13 Cu NE2 A:His120 2.11 Cu ND1 A:His120 4.24 Cu CD2 A:His120 2.89 Cu CE1 A:His120 3.23 Cu CG A:His120 4.11 Cu ZN A:Zn1157 1.15 Cu S A:So41159 4.45 Cu O1 A:So41159 3.16 Cu O2 A:So41159 4.67 Cu O A:Hoh2265 3.31 interactive model: Copper binding site 2 out of 2 in 2vr8 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Copper in the PDB 2vr8. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: F: His46, F: His48, F: His63, F: Val118, F: His120, F: Zn1157, F: So41159, conact list: Atom Atom Distance (A) Cu O F:His46 4.65 Cu NE2 F:His46 3.91 Cu N F:His46 4.21 Cu CB F:His46 2.73 Cu ND1 F:His46 1.75 Cu CD2 F:His46 3.77 Cu C F:His46 4.62 Cu CE1 F:His46 2.92 Cu CG F:His46 2.55 Cu CA F:His46 4.02 Cu NE2 F:His48 2.07 Cu ND1 F:His48 4.19 Cu CD2 F:His48 2.93 Cu CE1 F:His48 3.14 Cu CG F:His48 4.11 Cu NE2 F:His63 3.66 Cu CD2 F:His63 3.95 Cu CE1 F:His63 4.50 Cu CG F:His63 4.92 Cu O F:Val118 4.58 Cu CB F:Val118 3.97 Cu CG2 F:Val118 4.64 Cu CG1 F:Val118 4.16 Cu NE2 F:His120 2.23 Cu ND1 F:His120 4.34 Cu CD2 F:His120 2.98 Cu CE1 F:His120 3.36 Cu CG F:His120 4.21 Cu ZN F:Zn1157 1.11 Cu S F:So41159 4.31 Cu O1 F:So41159 3.06 Cu O2 F:So41159 4.57 interactive model: