Atomistry » Copper » PDB 2vr7-2xv0 » 2vr8
Atomistry »
  Copper »
    PDB 2vr7-2xv0 »
      2vr8 »

Copper in PDB 2vr8: Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution

Enzymatic activity of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution

All present enzymatic activity of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution:
1.15.1.1;

Protein crystallography data

The structure of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution, PDB code: 2vr8 was solved by S.Antonyuk, X.Cao, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, J.Selverstone Valentine, S.S.Hasnain, P.J.Hart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.36
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 34.210, 56.647, 74.714, 90.00, 102.14, 90.00
R / Rfree (%) 11.3 / 15.3

Other elements in 2vr8:

The structure of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution also contains other interesting chemical elements:

Zinc (Zn) 6 atoms

Copper Binding Sites:

The binding sites of Copper atom in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution (pdb code 2vr8). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution, PDB code: 2vr8:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in 2vr8

Go back to Copper Binding Sites List in 2vr8
Copper binding site 1 out of 2 in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu1156

b:10.2
occ:0.25
ZN A:ZN1157 1.1 11.8 0.3
ND1 A:HIS46 1.8 15.8 1.0
NE2 A:HIS48 2.1 11.1 1.0
NE2 A:HIS120 2.1 11.4 1.0
CG A:HIS46 2.6 11.1 1.0
CB A:HIS46 2.8 11.4 1.0
CD2 A:HIS120 2.9 10.3 1.0
CE1 A:HIS46 2.9 12.1 1.0
CD2 A:HIS48 3.0 10.8 1.0
CE1 A:HIS48 3.2 10.7 1.0
O1 A:SO41159 3.2 9.9 0.5
CE1 A:HIS120 3.2 10.8 1.0
O A:HOH2265 3.3 25.6 0.5
NE2 A:HIS63 3.7 12.5 1.0
CD2 A:HIS46 3.8 12.4 1.0
CD2 A:HIS63 3.9 12.5 1.0
NE2 A:HIS46 3.9 13.1 1.0
CB A:VAL118 3.9 8.3 1.0
CA A:HIS46 4.0 9.0 1.0
CG A:HIS120 4.1 8.7 1.0
CG1 A:VAL118 4.1 8.4 1.0
N A:HIS46 4.1 8.1 1.0
CG A:HIS48 4.2 9.4 1.0
ND1 A:HIS48 4.2 9.9 1.0
ND1 A:HIS120 4.2 9.9 1.0
S A:SO41159 4.5 9.9 0.5
O A:VAL118 4.5 8.2 1.0
CE1 A:HIS63 4.6 10.1 1.0
C A:HIS46 4.6 8.0 1.0
O A:HIS46 4.6 8.6 1.0
CG2 A:VAL118 4.7 8.9 1.0
O2 A:SO41159 4.7 10.8 0.5
CG A:HIS63 4.9 11.7 1.0
C A:VAL118 4.9 7.5 1.0

Copper binding site 2 out of 2 in 2vr8

Go back to Copper Binding Sites List in 2vr8
Copper binding site 2 out of 2 in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.36 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cu1156

b:12.6
occ:0.25
ZN F:ZN1157 1.1 11.1 0.3
ND1 F:HIS46 1.8 14.3 1.0
NE2 F:HIS48 2.1 10.8 1.0
NE2 F:HIS120 2.2 11.3 1.0
CG F:HIS46 2.6 11.4 1.0
CB F:HIS46 2.7 11.9 1.0
CE1 F:HIS46 2.9 14.1 1.0
CD2 F:HIS48 2.9 10.8 1.0
CD2 F:HIS120 3.0 11.8 1.0
O1 F:SO41159 3.1 9.5 0.7
CE1 F:HIS48 3.1 10.1 1.0
CE1 F:HIS120 3.4 11.6 1.0
NE2 F:HIS63 3.7 13.3 1.0
CD2 F:HIS46 3.8 13.4 1.0
NE2 F:HIS46 3.9 12.5 1.0
CD2 F:HIS63 4.0 12.3 1.0
CB F:VAL118 4.0 7.7 1.0
CA F:HIS46 4.0 9.0 1.0
CG F:HIS48 4.1 8.9 1.0
CG1 F:VAL118 4.2 9.4 1.0
ND1 F:HIS48 4.2 9.4 1.0
N F:HIS46 4.2 8.3 1.0
CG F:HIS120 4.2 9.9 1.0
S F:SO41159 4.3 11.9 0.7
ND1 F:HIS120 4.3 11.7 1.0
CE1 F:HIS63 4.5 9.9 1.0
O2 F:SO41159 4.6 14.0 0.7
O F:VAL118 4.6 8.6 1.0
C F:HIS46 4.6 7.7 1.0
CG2 F:VAL118 4.6 8.4 1.0
O F:HIS46 4.6 9.1 1.0
CG F:HIS63 4.9 11.2 1.0

Reference:

X.Cao, S.Antonyuk, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, J.Selverstone Valentine, S.S.Hasnain, P.J.Hart. Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis. J.Biol.Chem. V. 283 16169 2008.
ISSN: ISSN 0021-9258
PubMed: 18378676
DOI: 10.1074/JBC.M801522200
Page generated: Sun Dec 13 11:07:16 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy