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Copper in PDB 2vr7: Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution

Enzymatic activity of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution

All present enzymatic activity of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution:
1.15.1.1;

Protein crystallography data

The structure of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution, PDB code: 2vr7 was solved by S.Antonyuk, X.Cao, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, J.Selverstone Valentine, S.S.Hasnain, P.J.Hart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.58
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 36.768, 56.435, 75.028, 90.00, 102.98, 90.00
R / Rfree (%) 13.5 / 17.5

Copper Binding Sites:

The binding sites of Copper atom in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution (pdb code 2vr7). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution, PDB code: 2vr7:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in 2vr7

Go back to Copper Binding Sites List in 2vr7
Copper binding site 1 out of 2 in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu1155

b:17.1
occ:0.30
ZN A:ZN1156 1.1 10.3 0.7
ND1 A:HIS46 1.7 12.4 1.0
NE2 A:HIS120 2.1 7.7 1.0
NE2 A:HIS48 2.2 8.9 1.0
CG A:HIS46 2.5 8.8 1.0
CB A:HIS46 2.7 9.5 1.0
CD2 A:HIS120 2.8 8.7 1.0
CE1 A:HIS46 2.9 12.9 1.0
CD2 A:HIS48 3.0 10.0 1.0
O1 A:SO41158 3.1 6.5 0.7
CE1 A:HIS120 3.3 9.3 1.0
CE1 A:HIS48 3.3 9.5 1.0
NE2 A:HIS63 3.7 13.4 1.0
CD2 A:HIS46 3.7 10.4 1.0
NE2 A:HIS46 3.9 10.4 1.0
CA A:HIS46 4.0 7.4 1.0
CG A:HIS120 4.1 6.4 1.0
CB A:VAL118 4.1 5.9 1.0
CD2 A:HIS63 4.1 12.9 1.0
CG1 A:VAL118 4.2 8.1 1.0
N A:HIS46 4.2 8.2 1.0
ND1 A:HIS120 4.2 8.1 1.0
CG A:HIS48 4.2 5.9 1.0
S A:SO41158 4.3 9.0 0.7
ND1 A:HIS48 4.3 8.2 1.0
O A:VAL118 4.5 6.9 1.0
CE1 A:HIS63 4.5 10.3 1.0
O2 A:SO41158 4.6 9.3 0.7
C A:HIS46 4.7 7.3 1.0
O A:HIS46 4.7 7.3 1.0
CG2 A:VAL118 4.7 7.2 1.0

Copper binding site 2 out of 2 in 2vr7

Go back to Copper Binding Sites List in 2vr7
Copper binding site 2 out of 2 in the Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of G85R Als Mutant of Human Cu,Zn Superoxide Dismutase (Cuznsod) at 1.58 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cu1155

b:18.4
occ:0.30
ZN F:ZN1156 1.0 9.7 0.7
ND1 F:HIS46 1.8 11.8 1.0
NE2 F:HIS48 2.1 7.9 1.0
NE2 F:HIS120 2.1 8.7 1.0
CG F:HIS46 2.6 8.6 1.0
CB F:HIS46 2.8 8.9 1.0
CD2 F:HIS120 2.9 9.2 1.0
CD2 F:HIS48 2.9 9.6 1.0
O1 F:SO41158 3.0 6.2 0.7
CE1 F:HIS46 3.0 10.2 1.0
CE1 F:HIS48 3.2 10.8 1.0
CE1 F:HIS120 3.2 9.3 1.0
NE2 F:HIS63 3.8 11.0 1.0
CD2 F:HIS46 3.8 9.1 1.0
NE2 F:HIS46 4.0 9.2 1.0
CB F:VAL118 4.0 7.0 1.0
CA F:HIS46 4.1 7.7 1.0
CG F:HIS120 4.1 7.9 1.0
CD2 F:HIS63 4.1 10.4 1.0
CG F:HIS48 4.1 6.3 1.0
CG1 F:VAL118 4.2 7.2 1.0
S F:SO41158 4.2 8.8 0.7
ND1 F:HIS48 4.2 7.9 1.0
ND1 F:HIS120 4.2 8.6 1.0
N F:HIS46 4.3 7.5 1.0
O2 F:SO41158 4.4 8.9 0.7
O F:VAL118 4.6 7.1 1.0
CE1 F:HIS63 4.6 10.6 1.0
C F:HIS46 4.7 7.4 1.0
CG2 F:VAL118 4.7 8.4 1.0
O F:HIS46 4.7 7.3 1.0

Reference:

X.Cao, S.Antonyuk, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, J.S.Valentine, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, S.S.Hasnain, P.J.Hart. Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis. J.Biol.Chem. V. 283 16169 2008.
ISSN: ISSN 0021-9258
PubMed: 18378676
DOI: 10.1074/JBC.M801522200
Page generated: Thu Sep 3 16:52:02 2020
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