Copper in the structure of Crystal Structure Analysis of Coagulation Factor VIII (pdb 2r7e)

The binding sites of Copper atom in the structure of Crystal Structure Analysis of Coagulation Factor VIII (pdb code 2r7e). This binding sites where shown with 5.0 Angstroms radius around Copper atom. The 2r7e structure was solved by B.L.STODDARD, B.W.SHEN, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 57.4-3.7 Space group P41212 a (A) 134.569 b (A) 134.569 c (A) 359.496 alpha (°) 90.00 beta (°) 90.00 gamma (°) 90.00 Rfactor (%) 27.9 Rfree (%) 34.7 Copper Binding Sites: Copper binding site 1 out of 2 in 2r7e Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Copper in the PDB 2r7e. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Val266, A: His267, A: Ser268, A: Cys310, A: Ile312, A: His315, conact list: Atom Atom Distance (A) Cu O A:Val266 4.06 Cu C A:Val266 4.55 Cu O A:His267 4.68 Cu NE2 A:His267 2.61 Cu N A:His267 4.16 Cu CB A:His267 3.11 Cu ND1 A:His267 2.22 Cu CD2 A:His267 2.54 Cu C A:His267 3.57 Cu CE1 A:His267 2.44 Cu CG A:His267 2.29 Cu CA A:His267 2.93 Cu O A:Ser268 3.95 Cu N A:Ser268 3.41 Cu C A:Ser268 4.74 Cu CA A:Ser268 4.63 Cu CB A:Cys310 3.86 Cu SG A:Cys310 2.28 Cu CA A:Cys310 4.92 Cu CB A:Ile312 4.34 Cu CD1 A:Ile312 2.25 Cu CG1 A:Ile312 3.24 Cu NE2 A:His315 4.00 Cu CB A:His315 3.39 Cu ND1 A:His315 1.97 Cu CD2 A:His315 4.07 Cu CE1 A:His315 2.88 Cu CG A:His315 2.99 Cu CA A:His315 4.93 interactive model: Copper binding site 2 out of 2 in 2r7e Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Copper in the PDB 2r7e. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: B: His1954, B: Cys2000, B: Ile2002, B: His2005, B: Leu2006, B: Met2010, conact list: Atom Atom Distance (A) Cu NE2 B:His1954 3.88 Cu CB B:His1954 4.46 Cu ND1 B:His1954 2.31 Cu CD2 B:His1954 4.41 Cu CE1 B:His1954 2.56 Cu CG B:His1954 3.65 Cu CA B:His1954 4.53 Cu O B:Cys2000 4.95 Cu CB B:Cys2000 3.77 Cu SG B:Cys2000 2.26 Cu O B:Ile2002 4.21 Cu N B:Ile2002 4.78 Cu CB B:Ile2002 2.96 Cu CD1 B:Ile2002 2.76 Cu CG2 B:Ile2002 3.19 Cu C B:Ile2002 4.77 Cu CG1 B:Ile2002 3.31 Cu CA B:Ile2002 4.34 Cu NE2 B:His2005 4.66 Cu N B:His2005 4.24 Cu CB B:His2005 2.66 Cu ND1 B:His2005 2.64 Cu CD2 B:His2005 4.25 Cu C B:His2005 4.60 Cu CE1 B:His2005 3.86 Cu CG B:His2005 2.97 Cu CA B:His2005 3.96 Cu N B:Leu2006 4.99 Cu SD B:Met2010 4.85 interactive model: