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Copper in PDB 2pnc: Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine

Enzymatic activity of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine

All present enzymatic activity of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine:
1.4.3.6;

Protein crystallography data

The structure of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine, PDB code: 2pnc was solved by L.Cendron, A.Holt, D.J.Smith, G.Zanotti, A.Rigo, M.L.Di Paolo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.11 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.360, 131.956, 134.159, 90.00, 90.00, 90.00
R / Rfree (%) 23.7 / 25.2

Copper Binding Sites:

The binding sites of Copper atom in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine (pdb code 2pnc). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine, PDB code: 2pnc:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in 2pnc

Go back to Copper Binding Sites List in 2pnc
Copper binding site 1 out of 2 in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu804

b:29.2
occ:1.00
O4 A:TPQ470 2.1 35.7 1.0
ND1 A:HIS683 2.1 19.8 1.0
NE2 A:HIS519 2.1 16.1 1.0
NE2 A:HIS521 2.1 36.6 1.0
CE1 A:HIS683 2.8 19.8 1.0
CE1 A:HIS521 3.0 34.0 1.0
CD2 A:HIS519 3.1 10.5 1.0
CE1 A:HIS519 3.2 5.1 1.0
CD2 A:HIS521 3.2 34.9 1.0
CG A:HIS683 3.3 13.9 1.0
C4 A:TPQ470 3.3 35.5 1.0
O5 A:TPQ470 3.8 34.3 1.0
CB A:HIS683 3.9 18.0 1.0
C5 A:TPQ470 4.0 37.2 1.0
NE2 A:HIS683 4.0 9.6 1.0
ND1 A:HIS521 4.2 34.5 1.0
CG A:HIS519 4.2 12.2 1.0
ND1 A:HIS519 4.3 6.2 1.0
CD2 A:HIS683 4.3 11.4 1.0
CG A:HIS521 4.3 31.5 1.0
C3 A:TPQ470 4.4 36.6 1.0
O A:HOH901 4.5 21.8 1.0
CG2 A:ILE494 4.5 23.7 1.0

Copper binding site 2 out of 2 in 2pnc

Go back to Copper Binding Sites List in 2pnc
Copper binding site 2 out of 2 in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cu804

b:27.9
occ:1.00
NE2 B:HIS519 2.1 15.2 1.0
NE2 B:HIS521 2.1 33.5 1.0
O4 B:TPQ470 2.1 42.0 1.0
ND1 B:HIS683 2.2 18.6 1.0
CE1 B:HIS521 3.0 32.6 1.0
CE1 B:HIS683 3.0 20.2 1.0
CE1 B:HIS519 3.1 17.0 1.0
CD2 B:HIS519 3.1 19.9 1.0
CD2 B:HIS521 3.2 30.0 1.0
C4 B:TPQ470 3.2 40.5 1.0
CG B:HIS683 3.3 18.3 1.0
O B:HOH1021 3.6 50.0 1.0
CB B:HIS683 3.7 17.1 1.0
C3 B:TPQ470 4.0 42.3 1.0
C5 B:TPQ470 4.1 40.8 1.0
ND1 B:HIS521 4.2 34.4 1.0
ND1 B:HIS519 4.2 14.9 1.0
O5 B:TPQ470 4.2 37.5 1.0
NE2 B:HIS683 4.2 16.9 1.0
CG B:HIS519 4.2 18.4 1.0
CG B:HIS521 4.3 31.1 1.0
CD2 B:HIS683 4.4 14.8 1.0
O B:HOH902 4.4 26.4 1.0
CG2 B:ILE494 4.8 25.3 1.0

Reference:

A.Holt, D.J.Smith, L.Cendron, G.Zanotti, A.Rigo, M.L.Di Paolo. Multiple Binding Sites For Substrates and Modulators of Semicarbazide-Sensitive Amine Oxidases: Kinetic Consequences Mol.Pharmacol. V. 73 525 2008.
ISSN: ISSN 0026-895X
PubMed: 17989349
DOI: 10.1124/MOL.107.040964
Page generated: Thu Sep 3 16:47:01 2020
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