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Copper in PDB 2fk1: Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound

Protein crystallography data

The structure of Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound, PDB code: 2fk1 was solved by G.K.-W.Kong, M.W.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 16.83 / 1.60
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 31.437, 32.545, 50.402, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 23.2

Copper Binding Sites:

The binding sites of Copper atom in the Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound (pdb code 2fk1). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound, PDB code: 2fk1:

Copper binding site 1 out of 1 in 2fk1

Go back to Copper Binding Sites List in 2fk1
Copper binding site 1 out of 1 in the Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Structure of the Alzheimer'S Amyloid Precursor Protein (App) Copper Binding Domain in 'Small Unit Cell' Form, Cu(II)-Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu101

b:24.2
occ:0.51
OH A:TYR168 1.9 24.9 1.0
ND1 A:HIS151 1.9 17.4 1.0
NE2 A:HIS147 2.3 23.7 1.0
O A:HOH55 2.4 35.2 1.0
O A:HOH54 2.5 26.3 1.0
CE1 A:HIS151 2.8 17.6 1.0
CG A:HIS151 2.9 14.0 1.0
CZ A:TYR168 3.0 21.2 1.0
CD2 A:HIS147 3.1 21.1 1.0
CB A:HIS151 3.3 12.2 1.0
CE1 A:HIS147 3.3 24.5 1.0
CE2 A:TYR168 3.6 19.7 1.0
NE2 A:HIS151 3.9 15.9 1.0
CD2 A:HIS151 3.9 16.2 1.0
CE1 A:TYR168 4.0 19.4 1.0
CG A:HIS147 4.3 18.8 1.0
ND1 A:HIS147 4.4 23.7 1.0
CA A:HIS151 4.6 7.8 1.0
CD2 A:TYR168 4.9 17.8 1.0
O A:HIS147 4.9 10.8 1.0

Reference:

G.K.Kong, J.J.Adams, H.H.Harris, J.F.Boas, C.C.Curtain, D.Galatis, C.L.Masters, K.J.Barnham, W.J.Mckinstry, R.Cappai, M.W.Parker. Structural Studies of the Alzheimer'S Amyloid Precursor Protein Copper-Binding Domain Reveal How It Binds Copper Ions J.Mol.Biol. V. 367 148 2007.
ISSN: ISSN 0022-2836
PubMed: 17239395
DOI: 10.1016/J.JMB.2006.12.041
Page generated: Wed Oct 28 14:19:29 2020
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