Copper in PDB 1tu5: Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase

All present enzymatic activity of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase:
1.4.3.6;

The structure of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase, PDB code: 1tu5 was solved by M.Lunelli, M.L.Di Paolo, M.Biadene, V.Calderone, M.Scarpa, R.Battistutta, A.Rigo, G.Zanotti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 2.37
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.680, 131.192, 134.001, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 23.7

The structure of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase also contains other interesting chemical elements:

Chlorine	(Cl)	3 atoms
Calcium	(Ca)	4 atoms

The binding sites of Copper atom in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase (pdb code 1tu5). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase, PDB code: 1tu5:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu901 b:21.2 occ:1.00 ND1 A:HIS683 2.0 19.7 1.0 NE2 A:HIS521 2.1 22.2 1.0 NE2 A:HIS519 2.2 17.0 1.0 O A:HOH905 2.5 45.5 1.0 CD2 A:HIS521 2.9 23.2 1.0 CE1 A:HIS683 3.0 19.0 1.0 O A:HOH908 3.1 41.4 1.0 CG A:HIS683 3.1 19.0 1.0 CD2 A:HIS519 3.1 19.5 1.0 CE1 A:HIS519 3.2 18.0 1.0 CE1 A:HIS521 3.3 24.5 1.0 CB A:HIS683 3.5 20.4 1.0 NE2 A:HIS683 4.1 16.6 1.0 CG A:HIS521 4.2 23.6 1.0 CD2 A:HIS683 4.2 17.8 1.0 CG A:HIS519 4.3 19.9 1.0 ND1 A:HIS519 4.3 19.3 1.0 ND1 A:HIS521 4.3 23.2 1.0 O2 A:TPQ470 4.6 52.8 1.0 O A:HOH906 4.7 16.4 1.0 CE1 A:PHE681 4.9 17.6 1.0

Copper binding site 2 out of 2 in the Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cu901 b:23.9 occ:1.00 ND1 B:HIS683 2.0 19.2 1.0 NE2 B:HIS519 2.0 19.0 1.0 O B:HOH1906 2.2 33.4 1.0 NE2 B:HIS521 2.3 25.4 1.0 O B:HOH1907 2.8 45.3 1.0 CE1 B:HIS683 2.9 18.8 1.0 CE1 B:HIS519 3.0 20.6 1.0 CD2 B:HIS519 3.0 20.1 1.0 CG B:HIS683 3.0 19.2 1.0 CD2 B:HIS521 3.1 25.4 1.0 CE1 B:HIS521 3.4 26.7 1.0 CB B:HIS683 3.4 19.7 1.0 O2 B:TPQ470 3.9 56.5 1.0 NE2 B:HIS683 4.0 18.7 1.0 ND1 B:HIS519 4.1 22.6 1.0 CD2 B:HIS683 4.1 18.3 1.0 CG B:HIS519 4.1 21.6 1.0 O B:HOH1908 4.1 41.2 1.0 CG B:HIS521 4.3 23.6 1.0 ND1 B:HIS521 4.4 26.4 1.0 C2 B:TPQ470 4.7 55.2 1.0 C3 B:TPQ470 4.8 55.0 1.0 CE1 B:PHE681 4.9 18.1 1.0 CA B:HIS683 4.9 20.4 1.0

M.Lunelli, M.L.Di Paolo, M.Biadene, V.Calderone, R.Battistutta, M.Scarpa, A.Rigo, G.Zanotti. Crystal Structure of Amine Oxidase From Bovine Serum. J.Mol.Biol. V. 346 991 2005.
ISSN: ISSN 0022-2836
PubMed: 15701511
DOI: 10.1016/J.JMB.2004.12.038