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Copper in PDB 1sih: Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine")

Enzymatic activity of Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine")

All present enzymatic activity of Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine"):
1.4.3.6;

Protein crystallography data

The structure of Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine"), PDB code: 1sih was solved by J.M.Guss, D.B.Langley, A.P.Duff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.81 / 1.73
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 157.645, 62.787, 91.657, 90.00, 112.18, 90.00
R / Rfree (%) 14.9 / 16.8

Copper Binding Sites:

The binding sites of Copper atom in the Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine") (pdb code 1sih). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine"), PDB code: 1sih:

Copper binding site 1 out of 1 in 1sih

Go back to Copper Binding Sites List in 1sih
Copper binding site 1 out of 1 in the Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine")


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Agao in Covalent Complex with the Inhibitor Moba ("4-(4- Methylphenoxy)-2-Butyn-1-Amine") within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu701

b:26.8
occ:1.00
 NE2 A:HIS431 2.0 17.0 1.0
NE2 A:HIS433 2.1 20.5 1.0
ND1 A:HIS592 2.1 25.5 1.0
O A:HOH1368 2.6 37.7 1.0
CD2 A:HIS431 3.0 17.5 1.0
CD2 A:HIS433 3.0 23.8 1.0
CE1 A:HIS431 3.0 17.0 1.0
CE1 A:HIS592 3.0 24.0 1.0
CE1 A:HIS433 3.0 20.7 1.0
CG A:HIS592 3.1 24.6 1.0
HD2 A:HIS431 3.1 16.6 1.0
HB2 A:HIS592 3.1 17.2 1.0
HB3 A:HIS592 3.2 17.2 1.0
HD2 A:HIS433 3.2 21.0 1.0
HE1 A:HIS592 3.2 23.7 1.0
HE1 A:HIS433 3.2 19.7 1.0
HE1 A:HIS431 3.3 16.3 1.0
CB A:HIS592 3.3 17.6 1.0
HE2 A:MET602 4.1 30.4 0.5
ND1 A:HIS431 4.1 14.5 1.0
CG A:HIS431 4.1 14.5 1.0
ND1 A:HIS433 4.2 16.9 1.0
NE2 A:HIS592 4.2 21.4 1.0
CG A:HIS433 4.2 15.5 1.0
CD2 A:HIS592 4.2 22.4 1.0
O A:HOH1217 4.5 25.3 1.0
HE2 A:MET602 4.6 26.4 0.5
HE3 A:MET602 4.7 26.4 0.5
HG11 A:VAL406 4.8 27.5 1.0
HG3 A:PRO594 4.8 16.7 1.0
SD A:MET602 4.8 38.5 1.0
O A:HOH1503 4.8 41.0 1.0
CE A:MET602 4.8 26.9 0.5
CA A:HIS592 4.9 15.1 1.0
HQ3 A:MBQ382 4.9 27.7 1.0
CE A:MET602 4.9 21.0 0.5

Reference:

K.M.O'connell, D.B.Langley, E.M.Shepard, A.P.Duff, H.B.Jeon, G.Sun, H.C.Freeman, J.M.Guss, L.M.Sayre, D.M.Dooley. Differential Inhibition of Six Copper Amine Oxidases By A Family of 4-(Aryloxy)-2-Butynamines: Evidence For A New Mode of Inactivation. Biochemistry V. 43 10965 2004.
ISSN: ISSN 0006-2960
PubMed: 15323556
DOI: 10.1021/BI0492004
Page generated: Thu Sep 3 16:18:41 2020
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