Copper in the structure of X-Ray Analysis of Metal Substituted Human Carbonic Anhydrase II Derivatives (pdb 1rzc)

The binding sites of Copper atom in the structure of X-Ray Analysis of Metal Substituted Human Carbonic Anhydrase II Derivatives (pdb code 1rzc). This binding sites where shown with 5.0 Angstroms radius around Copper atom. The 1rzc structure was solved by K.HAKANSSON, A.WEHNERT, A.LILJAS, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 1.9 Space group P1211 a (A) 42.700 b (A) 41.700 c (A) 73.000 alpha (°) 90.00 beta (°) 104.60 gamma (°) 90.00 Rfactor (%) n/a Rfree (%) n/a Copper Binding Sites: Copper binding site 1 out of 2 in 1rzc Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Copper in the PDB 1rzc. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: His94, A: His96, A: Glu106, A: His119, A: Thr199, A: Oxy500, A: Hoh263, A: Hoh292, conact list: Atom Atom Distance (A) Cu NE2 A:His94 2.30 Cu ND1 A:His94 4.35 Cu CD2 A:His94 3.27 Cu CE1 A:His94 3.20 Cu CG A:His94 4.41 Cu NE2 A:His96 2.21 Cu ND1 A:His96 4.28 Cu CD2 A:His96 3.10 Cu CE1 A:His96 3.20 Cu CG A:His96 4.24 Cu OE1 A:Glu106 4.10 Cu CD A:Glu106 4.95 Cu NE2 A:His119 4.17 Cu CB A:His119 3.53 Cu ND1 A:His119 2.12 Cu CD2 A:His119 4.22 Cu CE1 A:His119 3.05 Cu CG A:His119 3.09 Cu OG1 A:Thr199 3.75 Cu O1 A:Oxy500 3.25 Cu O2 A:Oxy500 2.38 Cu O A:Hoh263 2.26 Cu O A:Hoh292 4.43 interactive model: Copper binding site 2 out of 2 in 1rzc Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Copper in the PDB 1rzc. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: His4, A: Trp5, A: Asn62, A: His64, A: Hoh332, conact list: Atom Atom Distance (A) Cu NE2 A:His4 2.47 Cu ND1 A:His4 4.13 Cu CD2 A:His4 3.70 Cu CE1 A:His4 2.88 Cu CG A:His4 4.58 Cu CZ2 A:Trp5 4.74 Cu CE2 A:Trp5 4.77 Cu NE1 A:Trp5 4.53 Cu O A:Asn62 4.24 Cu NE2 A:His64 2.55 Cu ND1 A:His64 3.84 Cu CD2 A:His64 4.52 Cu CD2 A:His64 3.94 Cu CE1 A:His64 2.56 Cu CG A:His64 4.54 Cu O A:Hoh332 3.91 interactive model: