Copper in the structure of Crystal Structure of the Human Cu, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (Fals) Mutant H43R (pdb 1ptz)

The binding sites of Copper atom in the structure of Crystal Structure of the Human Cu, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (Fals) Mutant H43R (pdb code 1ptz). This binding sites where shown with 5.0 Angstroms radius around Copper atom. The 1ptz structure was solved by M.DIDONATO, L.CRAIG, M.E.HUFF, M.M.THAYER, R.M.F.CARDOSO, C.J.KASSMANN, T.P.LO, C.K.BRUNS, E.T.POWERS, J.W.KELLY, E.D.GETZOFF, J.A.TAINER, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 29.1-1.8 Space group C121 a (A) 111.199 b (A) 47.525 c (A) 56.041 alpha (°) 90.00 beta (°) 97.99 gamma (°) 90.00 Rfactor (%) 18.6 Rfree (%) 21.5 Copper Binding Sites: Copper binding site 1 out of 2 in 1ptz Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Copper in the PDB 1ptz. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: His46, A: His48, A: His63, A: Val118, A: His120, A: Hoh350, conact list: Atom Atom Distance (A) Cu O A:His46 4.59 Cu NE2 A:His46 4.24 Cu N A:His46 4.18 Cu CB A:His46 3.31 Cu ND1 A:His46 2.13 Cu CD2 A:His46 4.23 Cu C A:His46 4.60 Cu CE1 A:His46 3.15 Cu CG A:His46 3.07 Cu CA A:His46 4.21 Cu NE2 A:His48 2.01 Cu ND1 A:His48 4.08 Cu CD2 A:His48 3.01 Cu CE1 A:His48 2.97 Cu CG A:His48 4.13 Cu NE2 A:His63 3.15 Cu ND1 A:His63 4.88 Cu CD2 A:His63 3.52 Cu CE1 A:His63 4.12 Cu CG A:His63 4.60 Cu O A:Val118 4.65 Cu CB A:Val118 4.11 Cu CG2 A:Val118 4.86 Cu CG1 A:Val118 4.33 Cu NE2 A:His120 2.04 Cu ND1 A:His120 4.14 Cu CD2 A:His120 2.98 Cu CE1 A:His120 3.05 Cu CG A:His120 4.14 Cu O A:Hoh350 3.59 interactive model: Copper binding site 2 out of 2 in 1ptz Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Copper in the PDB 1ptz. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Copper atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: B: His46, B: His48, B: His63, B: Val118, B: His120, B: Hoh417, conact list: Atom Atom Distance (A) Cu O B:His46 4.62 Cu NE2 B:His46 4.23 Cu N B:His46 4.32 Cu CB B:His46 3.54 Cu ND1 B:His46 2.20 Cu CD2 B:His46 4.31 Cu C B:His46 4.66 Cu CE1 B:His46 3.10 Cu CG B:His46 3.21 Cu CA B:His46 4.37 Cu NE2 B:His48 1.93 Cu ND1 B:His48 4.01 Cu CD2 B:His48 2.93 Cu CE1 B:His48 2.90 Cu CG B:His48 4.05 Cu NE2 B:His63 3.04 Cu ND1 B:His63 4.78 Cu CD2 B:His63 3.38 Cu CE1 B:His63 4.05 Cu CG B:His63 4.48 Cu O B:Val118 4.84 Cu CB B:Val118 4.20 Cu CG2 B:Val118 4.91 Cu CG1 B:Val118 4.44 Cu NE2 B:His120 2.05 Cu ND1 B:His120 4.15 Cu CD2 B:His120 3.02 Cu CE1 B:His120 3.05 Cu CG B:His120 4.17 Cu O B:Hoh417 3.31 interactive model: