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Copper in PDB 1iaa: Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity

Enzymatic activity of Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity

All present enzymatic activity of Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity:
3.4.24.21;

Protein crystallography data

The structure of Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity, PDB code: 1iaa was solved by F.-X.Gomis-Rueth, W.Stoecker, W.Bode, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 1.90
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 62.000, 62.000, 98.650, 90.00, 90.00, 120.00
R / Rfree (%) 15.6 / n/a

Copper Binding Sites:

The binding sites of Copper atom in the Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity (pdb code 1iaa). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total only one binding site of Copper was determined in the Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity, PDB code: 1iaa:

Copper binding site 1 out of 1 in 1iaa

Go back to Copper Binding Sites List in 1iaa
Copper binding site 1 out of 1 in the Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cu999

b:9.5
occ:1.00
NE2 A:HIS92 2.0 5.4 1.0
NE2 A:HIS102 2.1 5.2 1.0
NE2 A:HIS96 2.1 4.9 1.0
OH A:TYR149 2.1 3.8 1.0
O A:HOH300 2.2 8.3 1.0
CE1 A:HIS92 3.0 2.0 1.0
CD2 A:HIS102 3.0 2.0 1.0
CZ A:TYR149 3.0 7.8 1.0
CD2 A:HIS96 3.0 4.3 1.0
CE1 A:HIS102 3.1 9.9 1.0
CD2 A:HIS92 3.1 3.8 1.0
CE1 A:HIS96 3.1 3.1 1.0
CE1 A:TYR149 3.7 6.4 1.0
O A:HOH328 3.8 13.5 1.0
O A:HOH330 3.9 15.7 1.0
CE2 A:TYR149 3.9 5.5 1.0
O A:HOH357 4.1 11.3 1.0
ND1 A:HIS92 4.1 4.6 1.0
CG A:HIS102 4.2 9.1 1.0
ND1 A:HIS102 4.2 8.6 1.0
CG A:HIS96 4.2 10.2 1.0
CG A:HIS92 4.2 2.0 1.0
ND1 A:HIS96 4.2 2.4 1.0
OE1 A:GLU93 4.3 9.5 1.0
OE2 A:GLU93 4.7 11.6 1.0
CD A:GLU93 4.9 15.7 1.0
CD1 A:TYR149 5.0 3.1 1.0
CE A:MET147 5.0 3.2 1.0

Reference:

F.X.Gomis-Ruth, F.Grams, I.Yiallouros, H.Nar, U.Kusthardt, R.Zwilling, W.Bode, W.Stocker. Crystal Structures, Spectroscopic Features, and Catalytic Properties of Cobalt(II), Copper(II), Nickel(II), and Mercury(II) Derivatives of the Zinc Endopeptidase Astacin. A Correlation of Structure and Proteolytic Activity. J.Biol.Chem. V. 269 17111 1994.
ISSN: ISSN 0021-9258
PubMed: 8006015
Page generated: Sun Dec 13 10:59:19 2020

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