Copper in PDB 1aqp: Ribonuclease A Copper Complex

All present enzymatic activity of Ribonuclease A Copper Complex:
3.1.27.5;

The structure of Ribonuclease A Copper Complex, PDB code: 1aqp was solved by N.Ramasubbu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	58.180, 53.800, 42.900, 90.00, 118.90, 90.00
R / Rfree (%)	20 / n/a

The binding sites of Copper atom in the Ribonuclease A Copper Complex (pdb code 1aqp). This binding sites where shown within 5.0 Angstroms radius around Copper atom.
In total 2 binding sites of Copper where determined in the Ribonuclease A Copper Complex, PDB code: 1aqp:
Jump to Copper binding site number: 1; 2;

Copper binding site 1 out of 2 in the Ribonuclease A Copper Complex


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 1 of Ribonuclease A Copper Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu125 b:21.7 occ:1.00 HE2 A:HIS105 1.1 0.0 1.0 NE2 A:HIS105 2.0 11.7 1.0 O A:TYR76 2.3 14.0 1.0 CE1 A:HIS105 2.9 17.0 1.0 CD2 A:HIS105 3.1 13.9 1.0 C A:TYR76 3.5 13.7 1.0 CA A:SER77 4.0 15.7 1.0 ND1 A:HIS105 4.1 16.1 1.0 CG A:HIS105 4.2 16.7 1.0 N A:SER77 4.2 15.3 1.0 C A:SER77 4.5 17.6 1.0 CA A:TYR76 4.7 16.1 1.0 H A:THR78 4.7 0.0 1.0 N A:THR78 4.9 16.7 1.0 O A:SER75 4.9 9.4 1.0 HD1 A:HIS105 4.9 0.0 1.0

Copper binding site 2 out of 2 in the Ribonuclease A Copper Complex


Mono view


Stereo pair view

A full contact list of Copper with other atoms in the Cu binding site number 2 of Ribonuclease A Copper Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Cu147 b:39.0 occ:1.00 HE2 A:HIS119 1.2 0.0 1.0 NE2 A:HIS119 2.1 23.7 1.0 OE2 A:GLU111 2.1 26.4 1.0 O A:HOH180 2.1 40.9 1.0 O A:HOH146 2.4 35.9 1.0 H2 A:HOH180 2.5 0.0 1.0 O A:HOH128 2.6 12.9 1.0 CD A:GLU111 3.0 23.1 1.0 H1 A:HOH180 3.0 0.0 1.0 H2 A:HOH146 3.0 0.0 1.0 CD2 A:HIS119 3.0 20.4 1.0 H1 A:HOH146 3.1 0.0 1.0 CE1 A:HIS119 3.1 22.4 1.0 H2 A:HOH128 3.2 0.0 1.0 OE1 A:GLU111 3.2 28.4 1.0 H1 A:HOH128 3.3 0.0 1.0 CG A:HIS119 4.2 20.6 1.0 ND1 A:HIS119 4.2 23.2 1.0 CG1 A:VAL118 4.2 19.0 1.0 CG A:GLU111 4.4 18.7 1.0 O A:HOH203 4.7 35.3 1.0 O A:HOH202 4.7 39.2 1.0 H1 A:HOH203 4.9 0.0 1.0 H1 A:HOH144 5.0 0.0 1.0

R.Balakrishnan, N.Ramasubbu, K.I.Varughese, R.Parthasarathy. Crystal Structures of the Copper and Nickel Complexes of Rnase A: Metal-Induced Interprotein Interactions and Identification of A Novel Copper Binding Motif. Proc.Natl.Acad.Sci.Usa V. 94 9620 1997.
ISSN: ISSN 0027-8424
PubMed: 9275172
DOI: 10.1073/PNAS.94.18.9620